A novel one-pot synthesis of 3-acetyl- and 3-benzoylisoxazole derivatives using ammonium cerium nitrate (CAN)

Nitroalkanes as key building blocks for the synthesis of heterocyclic derivatives

“…54,60 Reaction of ketones 154 with cerium(IV) ammonium nitrate leads to nitro-ketones 155 that, under the same conditions, produce nitrile oxides, 156 (Scheme 36). 61,62 These 1,3-dipoles react with alkenes to give isoxazolines, 157, and with alkynes to give isoxazoles. Particularly, reaction of intermediate nitrile oxides 156 with the alkynyl glycosides 158 affords the isoxazoles 159, which are stable pharmacophores for glycomimetic syntheses.…”

Development of the New Approaches in Designing of Fluoroorganic Derivatives Sulfur (Unsaturated, Heterocyclic, Aromatic Molecular Systems and Polyfunctional Organic Compounds)

“…Products 1 -4 have been isolated by vacuum distillation. Their structures have been unambigously proved by 1 Н, 19 F and 13 С NMR spectroscopy. All products are formed by attack of F 5 S radical on terminal carbon atom, i.e., the studied photochemical reactions are completely regioselective.…”

“…Redistillation of this mixture at ambient pressure using rectification column allows to isolate 2-chloro-2,3,3-trifluoro-3-pentafluorosulfanylpropionic acid methyl ester in a yield of 34%. Its structure has been determined by 19 F NMR spectroscopy data (see Figure). The spectrum consists of four groups of signals in the region from -55 to +146 ppm.…”

Isoxazole derivatives as a potential insecticide for managing Callosobruchus chinensis

“…isouron, isoxaben and isoxathion, are effective as pesticides and are degradable, [4][5][6] and synthesis of isoxazole derivatives [7][8][9][10][11][12][13][14] was subsequently undertaken. Of these chemicals, isoxathion is an organophosphorus (OP) insecticide.…”