2016
DOI: 10.3389/fphar.2016.00049
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A Novel Pentapeptide Targeting Integrin β3-Subunit Inhibits Platelet Aggregation and Its Application in Rat for Thrombosis Prevention

Abstract: Background: Antiplatelet therapy plays a pivotal role in the prevention and treatment of thrombotic diseases. We reported the screening of P1C as a novel integrin-binding peptide from the C-terminal of connective tissue growth factor. Primary study indicated that P1C has potential against platelet aggregation.Objectives: We aimed to find the shortest active unit from the P1C fragments and explore its in vivo and in vitro activities.Methods: A series of truncated P1C fragments was prepared and screened for anti… Show more

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Cited by 2 publications
(2 citation statements)
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“…2017010). Healthy male specific-pathogen-free C57BL/6J mice (age, 8 weeks; weight, 19–21 g) were purchased from the Laboratory Animal Center of China Medical University, and cared for as reported previously ( 16 ). Mice were kept in a 12 h light-dark cycle, temperature-controlled (22±2°C) and humidity-controlled (55±5%) environment, and fed a standard chow diet for at least 1 week before experimentation.…”
Section: Methodsmentioning
confidence: 99%
“…2017010). Healthy male specific-pathogen-free C57BL/6J mice (age, 8 weeks; weight, 19–21 g) were purchased from the Laboratory Animal Center of China Medical University, and cared for as reported previously ( 16 ). Mice were kept in a 12 h light-dark cycle, temperature-controlled (22±2°C) and humidity-controlled (55±5%) environment, and fed a standard chow diet for at least 1 week before experimentation.…”
Section: Methodsmentioning
confidence: 99%
“…Fibrinogen, fibronectin, collagens, denatured collagen, decorsin, disintegrins, plasminogen, prothrombin, thrombospondin, vWf Cyclic peptides: KGD peptides [221,222] , RGD peptides [221,222] , integrilin (Eptifibatide) [223,224] Peptides: αIIb-TM [225] , GDV-peptides (e.g. γC-12) [226] , IRTPK (P1C) [227] Small molecules: Tirofiban (Aggreastat) [223] ,…”
Section: Integrinmentioning
confidence: 99%