A novel peptide-based electrochemical biosensor for breast cancer characterization over a poly 3-(3-aminophenyl) propionic acid matrix

Alves, Rafael da Fonseca; Martins, Isabella Castro; Franco, Diego Leoni; Silva, Adriane; Santos, Paula de Souza; Goulart, Luíz Ricardo; Maia, Yara Cristina de Paiva; Silva, Alinne; Araújo, Thaise Gonçalves; Sotomayor, Marı́a Del Pilar Taboada

doi:10.1016/j.bios.2022.114081

Cited by 19 publications

(7 citation statements)

References 39 publications

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“…A glassy carbon electrode (GCE) was modified with DNA-lead nanoparticles (Pb NPs) for sensitive and selective detection of the bacteria. In a study on biosensors for early detection of cancer, Alves et al (2022) developed a novel electrochemical biosensor for monitoring of breast cancer by immobilizing the biotin-C3 and biotin-H 2 peptides in the screen-printed electrodes/poly 3-(3-aminophenyl) propionic acid/ avidin system [10]. As we advanced deeper into the pandemic, we saw the need for advanced sensor technologies as a solution in the public health response to COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Nanostructures in Biosensors: Development and Applications

Karabulut¹,

Üllen²,

Karakuş³

2022

Biomedical Engineering

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In recent years, there has been significant interest in advanced nanobiosensor technologies with their exceptional properties for real-time monitoring, ultra-sensing, and rapid detection. With relevant experimental data, highly selective and hypersensitive detection of various analytes is possible using biosensors based on nanostructures. In particular, biosensors focus on vital issues such as disease early diagnosis and treatment, risk assessment of quality biomarkers, food-water quality control, and food safety. In the literature, there has been great attention to the preparation and sensing behavior of several nanomaterials-based sensors, such as polymer frameworks, metal-organic frameworks, one-dimensional (1D) nanomaterials, two-dimensional (2D) nanomaterials, and MXenes-based sensors. This chapter gives points to all aspects of fabrication, characterization, mechanisms, and applications of nanostructures-based biosensors. Finally, some smart advanced sensing systems for ultra-sensing nanoplatforms, as well as a comprehensive understanding of the sensor performances, current limitations, and future outlook of next-generation sensing materials, are highlighted.

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Section: Introductionmentioning

confidence: 99%

Nanostructures in Biosensors: Development and Applications

Karabulut¹,

Üllen²,

Karakuş³

2022

Biomedical Engineering

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“…Both synthetic peptides were shown to be capable of differentiating the serum samples of breast cancer patients from benign breast disease patients successfully. Besides, they were also tested to categorize patients with Luminal A and B breast tumours based on the expression of p53 and HER2 respectively [ 62 ].…”

Section: Discovery Of Phage-displayed Peptides For Targeting Various ...mentioning

confidence: 99%

Generation of peptides using phage display technology for cancer diagnosis and molecular imaging

et al. 2023

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Cancer is one of the leading causes of mortality worldwide; nearly 10 million people died from it in 2020. The high mortality rate results from the lack of effective screening approaches where early detection cannot be achieved, reducing the chance of early intervention to prevent cancer development. Non-invasive and deep-tissue imaging is useful in cancer diagnosis, contributing to a visual presentation of anatomy and physiology in a rapid and safe manner. Its sensitivity and specificity can be enhanced with the application of targeting ligands with the conjugation of imaging probes. Phage display is a powerful technology to identify antibody- or peptide-based ligands with effective binding specificity against their target receptor. Tumour-targeting peptides exhibit promising results in molecular imaging, but the application is limited to animals only. Modern nanotechnology facilitates the combination of peptides with various nanoparticles due to their superior characteristics, rendering novel strategies in designing more potent imaging probes for cancer diagnosis and targeting therapy. In the end, a myriad of peptide candidates that aimed for different cancers diagnosis and imaging in various forms of research were reviewed.

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“…43 By making use of phage display technology, da Fonseca Alves et al screened out two peptide ligands that selectively bound to luminal-type breast cancer cells, such as MCF-7. 44 The peptide ligands were immobilized at an electrode that was functionalized by a poly 3-(3-aminophenyl) propionic acid matrix, and applied to distinguish the molecular features of breast cancer patients based on the p53 status in the luminal A-subtype and the human epidermal growth factor receptor 2 (HER2) status in the luminal B-subtype by using square wave voltammetry (SWV) to monitor anionic current. By using a hydrosoluble polypeptide, octreotide, as the recognition ligand, Cong et al developed a sandwich-type electrochemical method for the detection of HeLa cells.…”

Section: Functional Peptide-based Electrochemical Biosensing Of Cance...mentioning

confidence: 99%

Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

et al. 2023

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A novel peptide-based electrochemical biosensor for breast cancer characterization over a poly 3-(3-aminophenyl) propionic acid matrix

Cited by 19 publications

References 39 publications

Nanostructures in Biosensors: Development and Applications

Nanostructures in Biosensors: Development and Applications

Generation of peptides using phage display technology for cancer diagnosis and molecular imaging

Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

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