A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate

Wang, Xingqi; Zhang, Yong; Huang, Jie; Tian, Chunling; Xia, Mengqiu; Liu, Liu; Li, Zhengguang; Cao, Jiaojiao; Gui, Shuangying; Chu, Xiaoqin

doi:10.1208/s12249-018-1248-0

Cited by 20 publications

(6 citation statements)

References 60 publications

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“…These peaks were indexed according to the Miller indices ( hkl ) of (110), (111), and (200) for the cubic space group Pn 3̅ m No peak was observed at the solid DLGL/PHY ratio of 0% w/w; therefore, the cubic phase could be prepared in the presence of DLGL under these conditions. Quite high concentration of PHY is required to create cubosomes comprising only PHY. − Therefore, DLGL is a key component for forming PHY cubosomes at low concentration of PHY and is equivalent to other stabilizers, such as amphiphilic block copolymers or PEGylated lipids. No diffraction peak was observed at the solid ratio of DLGL/PHY of 5% w/w; however, the peak pattern was completely different from that of DLGL/PHY of 0% w/w (Figure A).…”

Section: Resultsmentioning

confidence: 99%

Preparation of Cubosomes with Improved Colloidal and Structural Stability Using a Gemini Surfactant

Nagao,

Ranneh,

Iwao

et al. 2023

Mol. Pharmaceutics

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Cubosomes are nanoparticles with bicontinuous cubic internal nanostructures that have been considered for use in drug delivery systems (DDS). However, their low structural stability is a crucial concern for medical applications. Herein, we investigated the use of a gemini surfactant, sodium dilauramidoglutamide lysine (DLGL), which is composed of two monomeric surfactants linked with a spacer to improve the structural stability of cubosomes prepared with phytantriol (PHY). Uniform nanosuspensions comprising a specific mixing ratio of DLGL and PHY in water prepared via ultrasonication were confirmed by using dynamic light scattering. Small-angle X-ray scattering and cryo-transmission electron microscopy revealed the formation of Pn 3̅ m cubosomes in a range of DLGL/PHY solid ratios between 1 and 3% w/w. By contrast, cubosome formation was not observed at DLGL/PHY solid ratios of 5% w/w or higher, suggesting that excess DLGL interfered with cubosome formation and caused them to transform into small unilamellar vesicles. The addition of phosphate-buffered saline to the nanosuspension caused aggregation when the solid ratio of DLGL/PHY was less than 5% w/w. However, Im 3̅ m cubosomes were obtained at solid ratios of DLGL/PHY of 6, 7.5, and 10% w/w. The lattice parameters of the Pn 3̅ m and Im 3̅ m cubosomes were approximately 7 and 11–13 nm, respectively. The lattice parameters of Im 3̅ m cubosomes were affected by the concentration of DLGL. Pn 3̅ m cubosomes were surprisingly stable for 4 weeks at both 25 and 5 °C. In conclusion, DLGL, a gemini surfactant, was found to act as a new stabilizer for PHY cubosomes at specific concentrations. Cubosomes composed of DLGL are stable under low-temperature storage conditions, such as in refrigerators, making them a viable option for heat-sensitive DDS.

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Section: Resultsmentioning

confidence: 99%

Preparation of Cubosomes with Improved Colloidal and Structural Stability Using a Gemini Surfactant

Nagao,

Ranneh,

Iwao

et al. 2023

Mol. Pharmaceutics

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“…They have a high skin penetration capability, exceptional purity, and moisturizing ability. Furthermore, when synthesized in a PHYT-based liquid-crystalline matrix, sustained release dosage forms of hydrophilic pharmaceuticals demonstrated improved release capability [ 55 , 56 ]. As a result, in cubosome preparations, PHYT is usually seen to be a superior alternative for monoolein.…”

Section: Development Of Cubosomesmentioning

confidence: 99%

Development, Therapeutic Evaluation and Theranostic Applications of Cubosomes on Cancers: An Updated Review

Almoshari

2022

Pharmaceutics

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Cancer is a group of disorders characterized by aberrant gene function and alterations in gene expression patterns. In 2020, it was anticipated that 19 million new cancer cases would be diagnosed globally, with around 10 million cancer deaths. Late diagnosis and interventions are the leading causes of cancer-related mortality. In addition, the absence of comprehensive cancer therapy adds to the burden. Many lyotropic non-lamellar liquid-crystalline-nanoparticle-mediated formulations have been developed in the last few decades, with promising results in drug delivery, therapeutics, and diagnostics. Cubosomes are nano-structured liquid-crystalline particles made of specific amphiphilic lipids in particular proportions. Their ability to encapsulate lipophilic, hydrophilic, and amphiphilic molecules within their structure makes them one of a kind. They are biocompatible, versatile drug carriers that can deliver medications through various routes of administration. Many preclinical studies on the use of cubosomes in cancer treatment and theranostic applications have been conducted. However, before cubosomes may be employed in clinical practice, significant technical advances must be accomplished. This review summarizes the development of cubosomes and their multifunctional role in cancer treatment based on the most recent reports.

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“…To study the release mechanism of CA-ME, the following equations (zero-order, first-order, Higuchi, and Ritger-Peppas models; Wang et al, 2019) were used to fit the release data, respectively.…”

Section: In Vitro Releasementioning

confidence: 99%

In vitro and in vivo evaluation of cinnamaldehyde Microemulsion–Mucus interaction

Dong

Chen

Cai

et al. 2022

Journal of Food Biochemistry

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The current investigation explores the possible mechanism of the microemulsion drug delivery system to improve the oral bioavailability of cinnamaldehyde (CA), an important food spice, from the perspective of the microemulsion–mucus system. The cinnamaldehyde microemulsion (CA‐ME) was prepared by the water titration method combined with the pseudo‐ternary phase diagram. The dynamic analysis was applied to detect the drug release in vitro. An intestinal mucosal injury test was conducted to evaluate the safety of CA‐ME and drug absorption across the intestinal tract of rats was investigated through an Ussing chamber system. The rheology of blank mucus and drug‐loaded mucus was investigated using a rheometer. The bioavailability of CA‐ME in rats was evaluated through pharmacokinetic characteristics. The ratio of optimal prescription was Tween 80: 1,2‐propanediol: vitamin E oil: CA: water = 24.3:4.8:5:7.5:58.4. The droplets were uniform in size and evenly dispersed. Rheological studies showed that the microemulsion–mucus system all exhibit pseudoplastic fluid behavior, and CA‐ME increased the viscosity of the mucus to a certain extent. Compared with CA solution, CA‐ME promoted the absorption of CA in various intestinal segments, especially the ileum. Pharmacokinetic experiments showed that the relative bioavailability of CA‐ME was enhanced 2.5‐fold higher than that of CA solution. ME as a carrier for lipophobic substances, may increase the viscosity of the intestine mucus system to obtain longer residue time and better absorption. Practical applications In this study, in vitro absorption Ussing model was combined with rheological and pharmacokinetic analysis to systematically analyze the intestinal mucus mechanism of microemulsion to improve the oral bioavailability of cinnamic aldehyde. It laid the foundation for exploring the absorption and transport of drugs in the intestinal mucus barrier.

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A Novel Phytantriol-Based Lyotropic Liquid Crystalline Gel for Efficient Ophthalmic Delivery of Pilocarpine Nitrate

Cited by 20 publications

References 60 publications

Preparation of Cubosomes with Improved Colloidal and Structural Stability Using a Gemini Surfactant

Preparation of Cubosomes with Improved Colloidal and Structural Stability Using a Gemini Surfactant

Development, Therapeutic Evaluation and Theranostic Applications of Cubosomes on Cancers: An Updated Review

In vitro and in vivo evaluation of cinnamaldehyde Microemulsion–Mucus interaction

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