A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model

Ahmad, Aftab; Abuzinadah, Mohammed F.; Alkreathy, Huda M.; Kutbi, Hussam Ibrahim; Shaik, Noor Ahmad; Ahmad, Varish; Saleem, Sadaf; Husain, Asif

doi:10.4103/2221-1691.280292

Cited by 15 publications

(11 citation statements)

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“…PHE more effectively ceased the alteration of cytoplasmic components of renal tubules than that in the standard drug-treated diabetic rats (Figure ). Our results are comparable to the findings of Abuzinadah and Aftab (2020), who explained the nephron-protective effect of polyherbal formulations in cisplatin-induced hepatorenal injury by normalizing the renal architecture and restoring cellular organization/function . Another study also reported the nephron-protective effect of polyherbal formulations in carbon tetrachloride-induced hepatorenal injury in rats.…”

Section: Resultssupporting

confidence: 91%

“…Our results are comparable to the findings of Abuzinadah and Aftab (2020), who explained the nephron-protective effect of polyherbal formulations in cisplatin-induced hepatorenal injury by normalizing the renal architecture and restoring cellular organization/function. 27 Another study also reported the nephron-protective effect of polyherbal formulations in carbon tetrachloride-induced hepatorenal injury in rats. Polyherbal formulations caused tubular contraction, hydropic regeneration in the tubular epithelium, enhancement of the brush border on tubular epithelium cells, inhibition of tubular necrosis, and progression in the size of Bowman’s capsule.…”

Section: Resultsmentioning

confidence: 99%

“… 26 Earlier, Ahmad et al. (2020) also reported the effectiveness of a polyherbal formulation containing thymoquinone, which significantly decreased liver marker enzymes in carbon tetrachloride-induced hepatorenal injury in rats 27 …”

Section: Resultsmentioning

confidence: 99%

“…When glucose levels are increased in the blood, levels of liver enzymes also increase significantly, affecting normal metabolism. 26 Earlier, Ahmad et al (2020) also reported the effectiveness of a polyherbal formulation containing thymoquinone, which significantly decreased liver marker enzymes in carbon tetrachloride-induced hepatorenal injury in rats 27 Effect of the Polyherbal Extract on Insulin Levels in Diabetic Rats. The results of insulin determination in the blood showed a significant (p < 0.05) decrease in insulin levels of alloxan-treated rats as compared with the normal control group.…”

Section: Nanthine Et Al (2017)mentioning

confidence: 99%

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Biological and Hypoglycemic Effects of a Polyherbal Extract on Alloxanized Diabetic Rats

et al. 2022

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The current study investigates the antioxidant, antidiabetic, hepatoprotective, and nephroprotective potentials of a polyherbal mixture containing the methanolic extracts of seeds from Nigella sativa, Cicer arietinum, Silybum marianum, and Citrullus colocynthis and the rhizome of Zingiber officinale. The polyherbal extract (PHE) showed significant total phenolic contents (187.17 GAE/g), ferric reducing power (28%), and radical-scavenging activity (86.16%). The PHE also showed a substantial hypoglycemic effect in alloxan-induced diabetic rats by reducing the blood glucose level of the PHE-treated rats (−48.64%) and increasing the insulin level (107.5%) as compared with the diabetic control group. Likewise, an increase in high-density lipoprotein (HDL) contents (22.95%) with an associated decrease in low-density lipoprotein (LDL) levels (−43.93%) was also noted. A significant decrease in serum levels of liver marker enzymes, e.g., SGPT (−36%), SGOT (−31%), and serum ALP (−12%), was also observed as compared with the standard drug-treated group. Based on the findings of the study, it may be suggested that PHE helps ameliorate the severity of diabetes as a herbal remedy and might be employed in nutra-pharmaceuticals, replacing synthetic antidiabetic compounds.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Nanthine Et Al (2017)mentioning

confidence: 99%

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Biological and Hypoglycemic Effects of a Polyherbal Extract on Alloxanized Diabetic Rats

et al. 2022

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“…Ganoderma tsugae Polysaccharides [256,257] Gomphus clavatus Ergosterol, phenolic compounds [258,259] Grifola frondosa Phenolic compounds, β-1,6 and β-1,3-glucan [260] Helvella crispa Phenolic compounds [261] Hericium erinaceus Phenolic compounds [262] Hydnum repandum Tocopherols, phenolic compounds [263,264] I. obliquus p-Hydroxybenzoic acid, quercetin, kaempferol [265,266] Laccaria laccata Tocopherols, phenolic compounds [267] Lactarius citriolens Free sugars, fatty acids, tocopherols, and phenolic acids [268] Lactarius deliciosus Phenolic compounds, flavonoids [269][270][271] Lactarius piperatus Phenolic compounds, flavonoids [236,272] Lactarius salmonicolor Phenolic compounds [273,274] Lentinula edodes Gallic acid, protocatechuic acid, catechin, tocopherols [275][276][277] Lepista nuda β-Carotene, α-tocopherol [278][279][280][281] Leucopaxillus giganteus β-carotene, ascorbic acid, lycopene, phenolic compounds [282] Macrolepiota procera Phenolic compounds [283] Marasmius oreades Flavonoids, ascorbic acid [284,285] Meripilus giganteus Gallic, p-coumaric, protocatechin, caffeic, and vanillc acids [286][287][288] Phellinus igniarius Hispidin [289,290] Phellinus linteus β-Tocopherol, protocatechuic acid, gallic acid; pyrogallol; homogentisic acid, αand β-glucans [291] Pleurotus ostreatus β-Glucans galli...…”

Section: The Scientific Name Of the Mushroom Antioxidant Compounds Referencesmentioning

confidence: 99%

Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product

Chopra

Mishra

Baig

et al. 2021

JoF

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Mushrooms have remained an eternal part of traditional cuisines due to their beneficial health potential and have long been recognized as a folk medicine for their broad spectrum of nutraceuticals, as well as therapeutic and prophylactic uses. Nowadays, they have been extensively investigated to explain the chemical nature and mechanisms of action of their biomedicine and nutraceuticals capacity. Mushrooms belong to the astounding dominion of Fungi and are known as a macrofungus. Significant health benefits of mushrooms, including antiviral, antibacterial, anti-parasitic, antifungal, wound healing, anticancer, immunomodulating, antioxidant, radical scavenging, detoxification, hepatoprotective cardiovascular, anti-hypercholesterolemia, and anti-diabetic effects, etc., have been reported around the globe and have attracted significant interests of its further exploration in commercial sectors. They can function as functional foods, help in the treatment and therapeutic interventions of sub-optimal health states, and prevent some consequences of life-threatening diseases. Mushrooms mainly contained low and high molecular weight polysaccharides, fatty acids, lectins, and glucans responsible for their therapeutic action. Due to the large varieties of mushrooms present, it becomes challenging to identify chemical components present in them and their beneficial action. This article highlights such therapeutic activities with their active ingredients for mushrooms.

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Natural Antioxidants in Oxidative Stress‐Induced Diseases

Kalita

Deb

2022

Phytoantioxidants and Nanotherapeutics

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A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model

Cited by 15 publications

References 1 publication

Biological and Hypoglycemic Effects of a Polyherbal Extract on Alloxanized Diabetic Rats

Biological and Hypoglycemic Effects of a Polyherbal Extract on Alloxanized Diabetic Rats

Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product

Natural Antioxidants in Oxidative Stress‐Induced Diseases

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