A novel polysaccharide obtained from Siraitia grosvenorii alleviates inflammatory responses in a diabetic nephropathy mouse model via the TLR4-NF-κB pathway

Abstract

The inflammatory and antioxidant effects of a novel Siraitia grosvenorii polysaccharide (SGP-1-1) were investigated in an inflammation-suppressed diabetic nephropathy (DN) mouse model, and the underlying molecular mechanisms of inflammation and...

Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

“…Glycerophospholipid metabolism is closely associated with the inflammatory process, primarily the NF- κ B/p65 inflammatory signaling pathway [ 42 ]. Additionally, glycerophospholipid stimulates NF- κ B/p65 activation, resulting in the secretion of proinflammatory factors and an overall increase in inflammation-induced damage [ 43 ].…”

The novel anti-inflammatory activity of mcIRBP from Momordica charantia is associated with the improvement of diabetic nephropathy

“…40 A polysaccharide (SGP-1-1) from Siraitia grosvenorii alleviates inflammatory responses in a diabetic nephropathy mouse model via the TLR4-NF-κB pathway. 41 These findings also suggest that inhibition of inflammation might improve the progression of diabetic nephropathy. To elucidate how the mcIRBP ameliorated diabetic nephropathy, transcriptomic analysis was applied to determine the gene expression profiles affected by mcIRBP in kidneys.…”

Effects of simulated saliva‐gastrointestinal digestion on the physicochemical properties and bioactivities of Siraitia grosvenorii polysaccharides

“…The aqueous extraction and alcoholic precipitation of SGP were done according to a previously reported method (Gong et al ., 2021). In brief, SG was crushed, sieved, defatted in ethanol for 48 h, oven‐dried, and prepared for use.…”

“…SG has a sweet taste and low‐calorie content, in addition to its unique medicinal benefits of eliminating throat inflammation, moistening the lungs, removing phlegm, and regulating intestinal and liver function (Li et al ., 2014). SG is a popular kind of health‐promoting tea due to its richness in bioactive ingredients (Li et al ., 2014; Abdel‐Hamid et al ., 2020; Gong et al ., 2021). Polysaccharides, which are among the main active ingredients in SG, demonstrate a diverse range of biological activities, such as hypoglycemic activity (Gong et al ., 2021), blood lipid‐lowering effect, immunomodulatory effects, and antioxidant activity (Zhu et al ., 2020).…”

“…SG is a popular kind of health‐promoting tea due to its richness in bioactive ingredients (Li et al ., 2014; Abdel‐Hamid et al ., 2020; Gong et al ., 2021). Polysaccharides, which are among the main active ingredients in SG, demonstrate a diverse range of biological activities, such as hypoglycemic activity (Gong et al ., 2021), blood lipid‐lowering effect, immunomodulatory effects, and antioxidant activity (Zhu et al ., 2020). This, therefore, suggests the potential use of SG polysaccharides (SGPs) in functional food, healthcare, and pharmaceutical industries.…”