A novel prognostic nomogram for colorectal cancer liver metastasis patients with recurrence after hepatectomy

Liang, Jie; Lin, Haocheng; Li, Jingwen; Wang, De-Shen; Yuan, Yunfei; Li, Bin-Kui; Zheng, Yun; Wu, Xiaojun; Chen, Gong; Wang, Fenghua; Wang, Zhiqiang; Pan, Zhizhong; Wan, Desen; Xu, Rui‐Hua; Li, Yuhong

doi:10.1002/cam4.3697

Cited by 11 publications

(12 citation statements)

References 44 publications

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“…Although previous models have been created to predict the prognosis of stage IV CRC, these nomograms have shortcomings. Firstly, most of these studies have been conducted in relatively small populations, such as fewer than 1,000 cases in both Liang’s ( 34 ) and Beppu’s nomograms ( 35 ). Secondly, previous nomograms for the mCRC patients after liver metastases resection were presented, but the C-index was relatively low (about 0.6) ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study

Ge¹,

Zhou²,

Li³

et al. 2022

Transl Cancer Res TCR

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Background: The prognosis of rectal cancer patients with different metastatic status was significantly different. Our aim was to identify prognostic factors for metastatic rectal cancer (mRC) patients with different metastatic status and to construct specific nomograms to predict overall survival (OS).Methods: This study retrospectively analyzed mRC patients from 2010 to 2016 in the Surveillance, Epidemiology, and End Results Program database. All patients were ultimately divided into four groups: synchronous liver metastasis, synchronous lung metastasis, synchronous other organs metastasis and synchronous multiple metastases. Univariate and multivariate cox analyses were performed to screen out independent factors for each group. Individualized nomograms were constructed in different metastatic modes. The concordance index (C-index), decision curve analysis (DCA), time-dependent receiver operating characteristic (ROC) curve and calibration curve were performed to verify these nomograms.Results: Finally, 10,407 mRC patients were included in this study. Age, tumor grade, surgery of primary tumor, and chemotherapy were identified as common independent prognostic factors for each subgroup (all P<0.05). Other independent prognostic factors specific to each group included radiotherapy and marital status in the liver metastasis group, race, N stage, and the presence or absence of site-specific metastases in the multiple metastases group (all P<0.05). Higher T staging suggested worse OS in the group with liver, lung, and multiple site metastases. Individualized nomograms predicting 1-, 2-, and 3-year OS for each group were constructed by combining all independently significant risk factors in each group. The area under the curve (AUC) values and C-indexes of these nomograms created by each subgroup were greater than 0.7. All calibration curves and DCA curves showed that these nomograms had good clinical application significance.Conclusions: Individualized prognostic nomograms were constructed for mRC patients with different metastatic status based on different prognostic factors. These nomograms presented satisfactory predictive effects, which helps to provide survival assessment and individualized treatment decision-making for mRC patients with different metastatic status.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study

Ge¹,

Zhou²,

Li³

et al. 2022

Transl Cancer Res TCR

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“…Leakage is one of the most serious early complications of CRC surgery and there are many publications in the literature showing that it increases mortality and morbidity in the short term, although its effects on long-term mortality are not clear (28)(29)(30)(31). On the other hand, recurrence remains one of the most important clinical problems of curative CRC resection and there are publications in the literature that it is an indicator of poor prognosis (31)(32)(33)(34) The most important limitation of our study is that it is a retrospective study. Other limitations of our study are that it is a single-center study, the limited number of patients, and heterogeneous patient characteristics due to the inclusion of patients at all CRC stages.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Preoperative Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for their Predictive Value in Determining Short-Term Mortality in Patients with Operable Colorectal Cancers

ÖZDEMİR

Karayiğit

Dizen

et al. 2022

Düzce Tıp Fakültesi Dergisi

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Aim:The aim of this study was to investigate whether preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have a predictive value in short-term mortality in patients with operable colorectal cancer (CRC). Material and Methods: A total of 231 (93 female, 138 male) patients with operated CRC between 2016 and 2021 in a university hospital were analyzed retrospectively. Median age was 68 (range, 26-92) years and patients had been under follow-up for a median of 25 (range, 0-54) months. Patients were grouped with respect to survival, those who were alive (n=175) and those who died (n=56) during the follow-up. Results: The area under the curve for NLR was 0.649 (95% CI: 0.563-0.734, p=0.001), optimal cut-off was 5.08 and demonstrated a sensitivity of 48.2% and a specificity of 81.7% for predicting mortality. The area under the curve for PLR was 0.635 (95% CI: 0.546-0.723, p=0.002), optimal cut-off was 221.5 and demonstrated a sensitivity of 55.4% and a specificity of 72.0%. Multiple regression analysis revealed that recurrence (

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“…To an extent, the shape and growth pattern of colon carcinoma can reflect the biological characteristics of the carcinoma. [3] Postoperative pathology indicated that the cancer had invaded the serous layer (T4a). When the cancer invaded the visceral peritoneum, the cancer was able to invade the capillary venules, resulting in hematogenous metastasis.…”

Section: Pathogenesis and Metastasis Pathwaymentioning

confidence: 99%

Ascending colon cecal junction carcinoma with prostate metastasis: A case report and literature review

Zhu

et al. 2023

Medicine

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Rationale: Colon carcinoma is the most common type of cancer, and a leading cause of cancer-related death. Clinically, the most common sites of metastases from colon carcinoma are the liver, lungs, peritoneum, and lymph nodes, while the incidence of metastases to the prostate is low. There are few relevant studies on colon carcinoma, most of them being case reports. Patient concerns: A 76-year-old man treated with radical resection of right colon carcinoma due to primary poorly differentiated adenocarcinoma of the cecum. Postoperative pathological examination suggested that he had cancer at the junction of the ascending colon and the cecum. He had received adjuvant chemotherapy after surgery. One year later, he received transurethral plasma resection of the prostate due to urinary system discomfort. Postoperative pathological immunohistochemistry suggested prostate metastasis of colorectal carcinoma, and he received individualized treatment, but this produced no clear survival benefit. Diagnoses: Ascending colon cecal junction carcinoma with prostate metastasis. Interventions: Radical resection, chemotherapy, anti-androgen therapy, surgery to relieve primary lesion obstruction symptoms, and local radiotherapy of the prostate. Outcomes: At present, clinical cases of colon carcinoma with prostate metastasis are rare. By sharing a rare case of ascending colon cecal junction carcinoma with prostate metastasis and reviewing the relevant literature, this paper explores and optimizes the clinical treatment of colon carcinoma with prostate metastasis.

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A novel prognostic nomogram for colorectal cancer liver metastasis patients with recurrence after hepatectomy

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 44 publications

Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study

Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study

Evaluation of Preoperative Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for their Predictive Value in Determining Short-Term Mortality in Patients with Operable Colorectal Cancers

Ascending colon cecal junction carcinoma with prostate metastasis: A case report and literature review

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