A novel quinoline-based colorimetric fluorescent probe for hydrogen sulfide

Abstract

In this article, a novel fluorescent probe was designed and synthesized based on the quinoline structure for the detection of H2S. After optical evaluation, the probe showed good characteristics, including a fast response, high sensitivity, and good selectivity. More importantly, the probe could be directly observed by the naked eye after responding to H2S and has good application value.

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

“…Using related quinolinium, Fu reported 389, which provided a turn-off fluorescent response at 500 nm in 40% DMSO in buffer. 421 Modifying the central conjugation of these motifs, Chen and Liu reported related probe 390 (EMII-H 2 S), that is compatible with both one-and two-photon excitation at 410 and 750 nm, respectively. 422 This probe was used to image exogenous H 2 S in T24 cells and to investigate H 2 S in liver slices at scanning depths up to 180 μm.…”

“… This probe provides a turn-on response at 520 nm in buffer with 1 mM CTAB, showed moderate selectivity for H 2 S over thiols, and was used to investigate exogenous H 2 S in different vegetables. Using related quinolinium, Fu reported 389 , which provided a turn-off fluorescent response at 500 nm in 40% DMSO in buffer . Modifying the central conjugation of these motifs, Chen and Liu reported related probe 390 (EMII-H 2 S), that is compatible with both one- and two-photon excitation at 410 and 750 nm, respectively .…”