A novel ratiometric fluorescent probe for differential detection of HSO3− and ClO− and application in cell imaging and tumor recognition

Wu, Liangqiang; Qi, Shaolong; Liu, Yan; Wang, Xinyu; Zhu, Lubao; Yang, Qingbiao; Du, Jianshi; Xu, Hai; Li, Yaoxian

doi:10.1007/s00216-020-03077-7

Cited by 21 publications

(2 citation statements)

References 29 publications

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“…Moreover, HSO 3 − /H 2 O 2 imaging was successfully performed in adult zebrafish and nude mice. Unlike probe 53, probe 54 was proposed to identify HSO 3 − and ClO − by Wu [88] et al Using different emission channels, probe 54 caused strong fluorescence emission at 515 nm when interacting with ClO − and at 548 nm when interacting with HSO 3 − . In addition, the selectivity experiments showed that the probe has high selectivity and strong anti-interference ability.…”

Section: Based On Quinoline Fluorophorementioning

confidence: 99%

Small-Molecule Fluorescent Probe for Detection of Sulfite

Chen

Wang

et al. 2022

Pharmaceuticals

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Sulfite is widely used as an antioxidant additive and preservative in food and beverages. Abnormal levels of sulfite in the body is related to a variety of diseases. There are strict rules for sulfite intake. Therefore, to monitor the sulfite level in physiological and pathological events, there is in urgent need to develop a rapid, accurate, sensitive, and non−invasive approach, which can also be of great significance for the improvement of the corresponding clinical diagnosis. With the development of fluorescent probes, many advantages of fluorescent probes for sulfite detection, such as real time imaging, simple operation, economy, fast response, non−invasive, and so on, have been gradually highlighted. In this review, we enumerated almost all the sulfite fluorescent probes over nearly a decade and summarized their respective characteristics, in order to provide a unified platform for their standardized evaluation. Meanwhile, we tried to systematically review the research progress of sulfite small−molecule fluorescent probes. Logically, we focused on the structures, reaction mechanisms, and applications of sulfite fluorescent probes. We hope that this review will be helpful for the investigators who are interested in sulfite−associated biological procedures.

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Section: Based On Quinoline Fluorophorementioning

confidence: 99%

Small-Molecule Fluorescent Probe for Detection of Sulfite

Chen

Wang

et al. 2022

Pharmaceuticals

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“…[13][14][15][16] Various FL detection procedures have attracted widespread attention due to the reported benefits such as less sample damage, high sensitivity, and simple operation. 17,18 Most of the reported FL probes for HClO were designed based on the reaction between HClO/ClO − and the following recognition groups including chalcogenide (S, Se, and Te), 19 C=C unsaturated bond, p-methoxyphenyl or anisidine, N atomcontaining moieties (acyl hydrazine, acyl hydrazone, hydroxylamine, hydrazone, or Schiff bases). [20][21][22][23] Regrettably, the low sensitivity and unsatisfactory practicability of the probes hinder greatly the robust application, thus causing a great need for new design and synthesis based on the mature mechanism and light stable chromophore.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Biomass-Based Platform for Detection of ClO⁻ in Cells and Water-Soluble Systems

Nie,

Tang,

Wei

et al. 2024

Appl Spectrosc

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The generation and presence of excessive hypochlorous acid derivative ionic form (ClO−) could cause various diseases, such as arteriosclerosis, DNA damage, and cardiovascular illness. It is a critical need to develop a highly sensitive sensor for reliable detection of ClO− in cells and water-soluble systems. In this work, a hydroxyl group has been introduced into the compound 2-amino-3-(((E)-4-(2-(2-(2-hydroxyethoxy)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)benzylidene)amino)maleonitrile (NDC) to increase its solubility in water, at the same time, the hydrazone unit was designed as a specific recognition group for the “off–on” fluorescence probe of ClO−. The probe NDC presents high selectivity, sensitivity, anti-interference, and low detection limit (67 nM) for ClO−. The recognition mechanism that ClO− breaks the C=N bond and forms the fluorescent compound 4-(2-(2-(2-hydroxyethoxy)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)benzaldehyde (ND-3) has been confirmed by time-of-flight mass spectrometry. The probe NDC presents a good performance in the actual test of water samples and can be designed as the test papers for the quick and convenient detection of ClO− range from 0 to 1 μM. Moreover, the practical application was demonstrated by the successful imaging of endogenous and exogenous ClO− in HeLa cells. Our fluorescent biomass-based platform opens vast possibilities for repeatability, sensitivity, and selectivity detection of ClO− in cells and water-soluble systems.

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A rationally designed fluorescent probe for sulfur dioxide and its derivatives: applications in food analysis and bioimaging

Fang,

Zheng,

Zhang

et al. 2023

Anal Bioanal Chem

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A novel ratiometric fluorescent probe for differential detection of HSO3− and ClO− and application in cell imaging and tumor recognition

Cited by 21 publications

References 29 publications

Small-Molecule Fluorescent Probe for Detection of Sulfite

Small-Molecule Fluorescent Probe for Detection of Sulfite

Fluorescent Biomass-Based Platform for Detection of ClO⁻ in Cells and Water-Soluble Systems

A rationally designed fluorescent probe for sulfur dioxide and its derivatives: applications in food analysis and bioimaging

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A novel ratiometric fluorescent probe for differential detection of HSO3− and ClO− and application in cell imaging and tumor recognition

Cited by 21 publications

References 29 publications

Small-Molecule Fluorescent Probe for Detection of Sulfite

Small-Molecule Fluorescent Probe for Detection of Sulfite

Fluorescent Biomass-Based Platform for Detection of ClO− in Cells and Water-Soluble Systems

A rationally designed fluorescent probe for sulfur dioxide and its derivatives: applications in food analysis and bioimaging

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Product

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Fluorescent Biomass-Based Platform for Detection of ClO⁻ in Cells and Water-Soluble Systems