A novel ReS2–Nb2CTx composite as a sensing platform for ultrasensitive and selective electrochemical detection of dipyramidole from human serum

Abstract

The electrochemical detection of dipyridamole (DIPY) is highly essential since it is extensively used for the treatment of cardiovascular diseases and to impart inhibitory effects for cancer patients. In this work, we report the development of a novel composite of MXene and ReS 2 (ReS 2 –Nb 2 CT x ) by hydrothermal method. It was found that Nb 2 CT x was partially oxidized and ReS 2 nanoparticles were distributed on the surface of Nb 2 CT x during the hydrothermal synthesis. The ReS 2 –Nb 2 CT x was used to modify carbon cloth electrodes and used for the electrochemical detection of DIPY. The ratio of ReS 2 was optimized in the composite by varying the atomic ratio from 4 to 9 and it was found that 6ReS 2 –Nb 2 CT x showed the best sensing characteristics owing to the optimum interaction between ReS 2 and Nb 2 CT x . The developed sensor was able to detect DIPY linearly in the range 100 pM–1 μM and achieved a limit of detection of (LOD) of 28 pM. The modified electrode exhibited excellent selectivity towards DIPY in the presence of other interferents in addition to its good storage stability and repeatability. Furthermore, the developed sensor was also used for the detection of DIPY in human serum samples. Thus, this work paves the way to develop MXene-based platform for fabrication of flexible device capable of monitoring the acute levels of DIPY. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s41127-022-00055-x.

Unveiling the capability of graphitic carbon nitride–rhenium disulfide nanocomposite as an electrochemical sensing platform for the detection of dimetridazole from human serum samples

“…The strong electron donating nature of nitrogen through the C-N covalent bonds, along with its intercalation with Re-S, enhances the active sites of electronic conductivity, making the CN-ReS 2 composite an ideal candidate for sensor platform development. 37,38 To the best of our knowledge, this is the first report introducing CN-ReS 2 composite for the development of an electrochemical sensor; here, we tested with DMZ. CN was synthesized by heating 2 g of melamine in a silica crucible at 823 K for 4 hours using a previously reported technique of thermal condensation.…”

Nb2CTx/Protonated Carbon Nitride Nanocomposite for Electrochemical Detection of Serotonin

“…The high resolution TEM image given in the inset describes the clear lattice fringes with an interplanar distance of 0.35 nm corresponding to the (002) plane of CN 35 and an interlayer spacing of 1 nm corresponding to Nb 2 CT x . 36 Thus, the morphological characterization clearly defines the strong electrostatic interaction between PCN and MXene layers, which creates fine attachment between the layers.…”

“…43 However, the (002) peak of Nb 2 CT x is diminished and it can be due to the coverage of PCN on the surface of Nb 2 CT x . 36 Electrochemical Characterizations. The electrochemical analysis of CCT modified with different composites was conducted by employing cyclic voltammetry (CV) analysis in a solution comprising 0.1 mM KCl and 10 mM [Fe(CN) 6 ] 3−/4− solutions.…”

Conversion of Electronic Waste to an Electrochemical Sensor for Dopamine: Using MXene-Modified Liquid Crystal Display Panels

“…MXenes, a class of transitional metal carbides/nitrides, have gained popularity due to their appealing characteristics such as electron transport behavior, excellent conductivity, biocompatibility, and the capacity to create freestanding films . MXenes have been utilized in several sensing applications including gas molecules, such as ammonia and SO 2 in addition to the different biomolecules and drug molecules . MXenes have been utilized to modify the carbon cloth for the sensitive detection of DA after modifying Nb 2 CT x MXene with ethylene diamine .…”

“…27 MXenes have been utilized in several sensing applications including gas molecules, 28 such as ammonia 29 and SO 2 30 in addition to the different biomolecules 21 and drug molecules. 31 MXenes have been utilized to modify the carbon cloth for the sensitive detection of DA after modifying Nb 2 CT x MXene with ethylene diamine. 27 Similarly, Nb 2 CT x -MoS 2 nanocomposites 21 and Ti 3 C 2 T x with bimetallic phosphide have also been used to modify the carbon toward the sensitive detection of DA.…”