A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis

Rae, Dustin T.; Hocum, Jonah D.; Bii, Victor M.; Deeg, Joachim; Trobridge, Grant D.

doi:10.18632/oncotarget.5133

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Their pathological relevance and underlying mechanisms are unknown. Finally, another retroviral mutagenesis screen found insertions in Itpkb to synergize with a retrovirally expressed, AML-associated Runx1- mutant in promoting murine BM progenitor outgrowth ( 171 ). The same study found that ITPKB amplifications and mRNA upregulation associate with poor survival in human AML.…”

Section: Ip 4 Dampens Store-operated Ca mentioning

confidence: 99%

Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides

Elich

Sauer

2018

Front. Immunol.

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One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger phosphatidylinositol(3,4,5)trisphosphate (PIP3) by class I phosphoinositide 3 kinases (PI3K). Defective PIP3 signaling impairs almost every aspect of hematopoiesis, including T cell development and function. Limiting PIP3 signaling is particularly important, because excessive PIP3 function in lymphocytes can transform them and cause blood cancers. Here, we review the key functions of PIP3 and related phosphoinositides in hematopoietic cells, with a special focus on those mechanisms dampening PIP3 production, turnover, or function. Recent studies have shown that beyond “canonical” turnover by the PIP3 phosphatases and tumor suppressors phosphatase and tensin homolog (PTEN) and SH2 domain-containing inositol-5-phosphatase-1 (SHIP-1/2), PIP3 function in hematopoietic cells can also be dampened through antagonism with the soluble PIP3 analogs inositol(1,3,4,5)tetrakisphosphate (IP4) and inositol-heptakisphosphate (IP7). Other evidence suggests that IP4 can promote PIP3 function in thymocytes. Moreover, IP4 or the kinases producing it limit store-operated Ca2+ entry through Orai channels in B cells, T cells, and neutrophils to control cell survival and function. We discuss current models for how soluble inositol phosphates can have such diverse functions and can govern as distinct processes as hematopoietic stem cell homeostasis, neutrophil macrophage and NK cell function, and development and function of B cells and T cells. Finally, we will review the pathological consequences of dysregulated IP4 activity in immune cells and highlight contributions of impaired inositol phosphate functions in disorders such as Kawasaki disease, common variable immunodeficiency, or blood cancer.

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Section: Ip 4 Dampens Store-operated Ca mentioning

confidence: 99%

Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides

Elich

Sauer

2018

Front. Immunol.

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CCDC12 gene methylation in peripheral blood as a potential biomarker for breast cancer detection

Liu,

Qu,

Zhao

et al. 2024

Biomarkers

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Comprehensive analysis of prognostic alternative splicing signature in cervical cancer

et al. 2020

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Background Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were downloaded from The Cancer Genome Atlas (TCGA) SpliceSeq website. Few prognostic AS events were identified through univariate Cox analysis. We further identified the prognostic prediction models of the seven subtypes of AS events and assessed their predictive power. We constructed a clinical prediction model through global analysis of prognostic AS events and established a nomogram using the risk score calculated from the prognostic model and relevant clinical information. Unsupervised cluster analysis was used to explore the relationship between prognostic AS events in the model and clinical features. Results A total of 2860 prognostic AS events in cervical cancer were identified. The best predictive effect was shown by a single alternate acceptor subtype with an area under the curve of 0.96. Our clinical prognostic model included a nine-AS event signature, and the c-index of the predicted nomogram model was 0.764. SNRPA and CCDC12 were hub genes for prognosis-associated splicing factors. Unsupervised cluster analysis through the nine prognostic AS events revealed three clusters with different survival patterns. Conclusions AS events affect the prognosis and biological progression of cervical cancer. The identified prognostic AS events and splicing regulatory networks can increase our understanding of the underlying mechanisms of cervical cancer, providing new therapeutic strategies.

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A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis

Cited by 4 publications

References 34 publications

Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides

Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides

CCDC12 gene methylation in peripheral blood as a potential biomarker for breast cancer detection

Comprehensive analysis of prognostic alternative splicing signature in cervical cancer

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