A novel silk suture-assisted laparoscopic technique for the repair of a gastrocolic fistula in a pediatric patient

Mughal, Seher; Shalaby, Aly; Curry, Joseph I.; Coppi, Paolo De; Cross, Kate

doi:10.1016/j.epsc.2016.07.007

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…[15,16] Silk protein is a natural biopolymer renowned for its excellent biocompatibility, controllable degradation and adjustable mechanical properties. It has been successfully manufactured into various bio-functional devices, including tough sutures, [17,18] flexible electronics, [19,20] and robust bone screws, [21] which can be used in the fields of drug delivery, [22][23][24][25] tissue regeneration, [26][27][28] cell scaffolding, [29,30] implantable skull fixation systems [31] and soluble transient electronics/optics. [32,33] In this context, silk is a promising material for intracerebral drug delivery implants.…”

Section: Introductionmentioning

confidence: 99%

Silk Microneedle Patch Capable of On‐Demand Multidrug Delivery to the Brain for Glioblastoma Treatment

et al. 2021

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Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Surgery followed by chemotherapy and radiotherapy remains the standard treatment strategy for GBM patients. However, challenges still exist when surgery is difficult or impossible to remove the tumor completely. Herein, the design, fabrication and application of a heterogenous silk fibroin microneedle (SMN) patch is reported for circumventing the blood‐brain barrier and releasing multiple drugs directly to the tumor site for drug combination treatment. The biocompatible and biodegradable SMN patch can dissolve slowly over time, allowing the sustained release of multiple drugs at different doses. Furthermore, it can be triggered remotely to induce rapid drug delivery at a designated stage after implantation. In the GBM mouse models, two clinically relevant chemotherapeutic agents (thrombin and temozolomide) and targeted drug (bevacizumab) are loaded into the SMN patch with individually controlled release profiles. The drugs are spatiotemporally and sequentially delivered for hemostasis, anti‐angiogenesis, and apoptosis of tumor cells. Device application is non‐toxic and results in decreased tumor volume and increased survival rate in mice. The SMN patch with on‐demand multidrug delivery has potential applications for the combined administration of therapeutic drugs for the clinical treatment of brain tumors when other methods are insufficient.

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