A Novel Simple Gold Nanoparticles Pencil Electrode for Sensitive Voltametric Determination of Antiepileptic Drug Perampanel

Abstract

The construction and electroanalytical performance of a novel low-cost graphite pencil sensor enriched with electrodeposited gold nanoparticles (AuNPs/PE) was for sensitive voltammetric determination of perampanel (PER) in the marketed pharmaceutical samples and plasma. In BR buffer solution at pH 4.0, PER showed irreversible anodic peak at 1.15 V following an adsorption-electrode reaction. Based on the molecular orbital calculations and electroanalytical studies, the electrooxidation of PER undergoes through oxidation of the amide nitrogen atom (N3) with the transfer of two protons/one electron. Under the optimum measuring conditions, linear calibration graphs were illustrated covering a wide PER concentration ranged from 10 to 1295 ng mL-1 with limit of quantification and limit of detection values 10.0 and 3.03 ng mL-1, respectively. The proposed AuNPs/PE showed operational lifetime for 30 days and offer low-cost sensitive and selective electroanalytical approach for monitoring of PER without noticeable interference from additives, excipients, and PER degradation products. The fabricated AuNPs/PE was introduced for determination of PER in the marketed pharmaceutical formulations and spiked plasma samples.