A novel starch-based stimuli-responsive nanosystem for theranostic applications

Poorgholy, Nahid; Massoumi, Bakhshali; Jaymand, Mehdi

doi:10.1016/j.ijbiomac.2017.01.063

Cited by 48 publications

(21 citation statements)

References 59 publications

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“…The saturation magnetization (δ s ) of the Fe 3 O 4 NPs and MNHG were determined to be about 86.3 and 52.4 emug −1 , respectively. In comparison with similar systems, the developed MNHG exhibited higher magnetization value that qualified it for targeted drug delivery …”

Section: Resultsmentioning

confidence: 91%

“…The magnetic properties of magnetic hydrogels synthesized for drug-delivery purpose is a pivotal character which need to analysis to evaluate the targetability performance of final product. 4 We investigated the magnetic properties of Fe 3 O 4 NPs, and developed MNHG using VSM as shown in Figure 12 the developed MNHG exhibited higher magnetization value that qualified it for targeted drug delivery. 4,5,33,34 Dispersibility Test.…”

Section: Lcst Measurement Using Uv-vis Spectroscopymentioning

confidence: 99%

“…In a thermo‐responsive system, when temperature is increased above its LCST hydrophilic–hydrophobic transition occurs and leads to collapse of the structure. This transition resulted in the release of the encapsulated cargo (drug in the case of DDS) from the system …”

Section: Introductionmentioning

confidence: 99%

“…The demand for novel and more efficient drug-delivery systems (DSSs) have been attracted more and more research efforts over the last few decades, and the close working of material and polymer scientists with biologists leads to some convincing results in the field. [1][2][3][4][5] Among the DSSs, hydrogels are of particular interest mainly due to their some inherent physicochemical and biological characteristics including, porous structure, high water content, favorable structural features, biocompatibility, in vivo degradation by enzymatic or non-enzymatic hydrolysis, as well as efficient drug loading potential. [6][7][8] Hydrogels are threedimensional (3D) hydrophilic polymer network that are fabricated by chemical or physical crosslinking and can absorb a large amount of water while maintaining their shape.…”

Section: Introductionmentioning

confidence: 99%

“…This transition resulted in the release of the encapsulated cargo (drug in the case of DDS) from the system. [3][4][5] The objective of this research was to design and development of a novel stimuli-responsive magnetite nanohydrogel (MNHG) for application as DDS. For this purpose, epoxylated poly(ethylene glycol (PEG) was synthesized through the reaction of poly(ethylene glycol) monomethylether with epichlorohydrin (ECH), and subsequently hydrolyzed to PEG end-caped diol [PEG(OH) 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Mozaffari

Hatamzadeh

Massoumi

et al. 2018

J of Applied Polymer Sci

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A novel stimuli‐responsive magnetite nanohydrogel (MNHG), namely [poly(ethylene glycol)‐block‐poly(N‐isopropylacrylamide‐co‐maleic anhydride)2]‐graft‐poly(ethylene glycol)/Fe3O4 [PEG‐b‐(PNIPAAm‐co‐PMA)2]‐g‐PEG/Fe3O4, was successfully developed. For this purpose, NIPAAm and MA monomers were block copolymerized onto PEG‐based macroinitiator through atom transfer radical polymerization technique to produce PEG‐b‐(PNIPAAm‐co‐PMA)2. The synthesized Y‐shaped terpolymer was crosslinked through the esterification of maleic anhydride units using PEG chains to afford a hydrogel. Afterward, magnetite nanoparticles were incorporated into the synthesized hydrogel through the physical interactions. The chemical structures of all synthesized samples were characterized using Fourier transform infrared and proton nuclear magnetic resonance spectroscopies. Morphology, thermal stability, size, and magnetic properties of the synthesized MNHG were investigated. In addition, the doxorubicin hydrochloride loading and encapsulation efficiencies as well as stimuli‐responsive drug release ability of the synthesized MNHG were also evaluated. The drug‐loaded MNHG at physiological condition exhibited negligible drug release values. In contrast, at acidic (pH 5.3) condition and a little bit higher temperature (41 °C) the developed MNHG showed higher drug release values, which qualified it for cancer chemotherapy due to especial physiology of cancerous tissue in comparison with the surrounding normal tissue. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46657.

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Section: Resultsmentioning

confidence: 91%

Section: Lcst Measurement Using Uv-vis Spectroscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Mozaffari

Hatamzadeh

Massoumi

et al. 2018

J of Applied Polymer Sci

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Synthesis and characterization of a pH‐ and glucose‐responsive triblock copolymer via RAFT technique and its conjugation with gold nanoparticles for biomedical applications

Abbasian

Judi

Mahmoodzadeh

et al. 2018

Polymers for Advanced Techs

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A combination of ring-opening polymerization (ROP) and reversible addition of fragmentation chain transfer (RAFT) polymerization techniques was successfully employed for the synthesis of a novel pH-and glucose-responsive thiol-end-capped ABC triblock copolymer, namely, poly(acrylic acid)-block-poly(vinylphenylboronic acid)-block-poly(ε-caprolactone)-SH (PAA-b-PVPBA-b-PCL-SH). The synthesized triblock copolymer was characterized using Fourier transform infrared (FTIR) and proton nuclear magnetic resonance ( 1 H NMR) spectroscopies. The molecular weights of each segment in the synthesized triblock copolymer were calculated using both gel permeation chromatography (GPC) and 1 H NMR spectroscopy. The self-assembly behavior of the fabricated triblock copolymer under various pHs as well as in the presence of glucose were investigated using dynamic light scattering (DLS) measurement. The PAA-b-PVPBA-b-PCL-SH triblock copolymer was conjugated with gold nanoparticles (GNPs). In addition, the morphologies of GNPs, PAA-b-PVPBA-b-PCL-SH triblock copolymer, and GNPs@polymer were observed using transmission electron microscopy (TEM). As the results, the fabricated GNPs@Polymer can be employed as drug delivery system and micellar glucose biosensor.

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A novel dual stimuli-responsive thiol-end-capped ABC triblock copolymer: synthesis via reversible addition-fragmentation chain transfer technique, and investigation of its self-assembly behavior

et al. 2017

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A novel thermo-and pH-responsive thiol-end-capped ABC triblock copolymer, namely poly(acrylic acid)-block-poly(Nisopropylacrylamide)-block-poly( -caprolactone)-SH (PAA-b-PNIPAAm-b-PCL-SH), was synthesized using a combination of ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization techniques. The chemical structures of all samples were characterized by means of Fourier transform infrared and 1 H NMR spectroscopies. The molecular weight of each segment was investigated using both 1 H NMR spectroscopy and gel permeation chromatography. The self-assembly behavior of the PAA-b-PNIPAAm-b-PCL-SH triblock copolymer under thermal and pH stimuli was fully investigated by means of fluorescence and UV-visible spectroscopies as well as dynamic light scattering measurements. The critical micelle concentration for the synthesized triblock copolymer was determined to be 0.0178 g L −1 using the fluorescence probe technique. The average size of PAA-b-PNIPAAm-b-PCL-SH micelles was determined to be 25 nm using transmission electron microscopy observations, and its lower critical solution temperature was determined to be 41-43 ∘ C using UV-visible spectroscopy.

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A novel starch-based stimuli-responsive nanosystem for theranostic applications

Cited by 48 publications

References 59 publications

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Synthesis and characterization of a pH‐ and glucose‐responsive triblock copolymer via RAFT technique and its conjugation with gold nanoparticles for biomedical applications

A novel dual stimuli-responsive thiol-end-capped ABC triblock copolymer: synthesis via reversible addition-fragmentation chain transfer technique, and investigation of its self-assembly behavior

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