A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug‐Loaded Nanofibrous Patches

Cesur, Sümeyye; Ilhan, Elif; Pilavci, Esra; Sulutas, Rabia Betul; Gürboğa, Merve; Özakpınar, Özlem Bingöl; Kaya, Elif; Heljak, Marcin; Tinaz, Gulgun Bosgelmez; Oktar, Faik N.; Gündüz, Oğuzhan; Kijeńska‐Gawrońska, Ewa

doi:10.1002/mame.202370009

Cited by 3 publications

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“…N–H bending is seen at ∼1525 cm –1 . The peak at ∼1626 cm –1 indicates the C–O stretching . In Figure A,b, absorption peaks of pure PVA are shown.…”

Section: Resultsmentioning

confidence: 99%

“…The peak detected at 190.98 °C for the PVA/GEL nanofiber patches represents the endothermic curve. The glass-transition temperature of PVA is in the range of 50–60 °C . For PVA/GEL, PVA/GEL/CA, PVA/GEL/GEN, and PVA/GEL/CA/GEN, the glass-transition temperatures were observed at 59.42, 61.07, 63.13, and 62.87 °C, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The peak at ∼1626 cm –1 indicates the C–O stretching. 36 In Figure 3 A,b, absorption peaks of pure PVA are shown. The peak at ∼3268 cm –1 is related to O–H stretching, which confirms the intramolecular and intermolecular hydrogen bonds.…”

Section: Resultsmentioning

confidence: 99%

“…The glasstransition temperature of PVA is in the range of 50−60 °C. 36 For PVA/GEL, PVA/GEL/CA, PVA/GEL/GEN, and PVA/ GEL/CA/GEN, the glass-transition temperatures were observed at 59.42, 61.07, 63.13, and 62.87 °C, respectively. There was a slight shift in glass-transition temperatures with the addition of CA and GEN drugs to the non-drug-containing PVA/GEL nanofiber patches.…”

Section: Morphology Of the Nanofibrous Patchesmentioning

confidence: 99%

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Design of Cinnamaldehyde- and Gentamicin-Loaded Double-Layer Corneal Nanofiber Patches with Antibiofilm and Antimicrobial Effects

et al. 2023

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In this study, two-layer poly(vinyl alcohol)/gelatin (PVA/GEL) nanofiber patches containing cinnamaldehyde (CA) in the first layer and gentamicin (GEN) in the second layer were produced by the electrospinning method. The morphology, chemical structures, and thermal temperatures of the produced pure (PVA/GEL), CA-loaded (PVA/GEL/CA), GEN-loaded (PVA/GEL/GEN), and combined drug-loaded (PVA/GEL/CA/GEN) nanofiber patches were determined by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and differential scanning calorimetry, respectively. Their mechanical properties, swelling and degradation behavior, and drug release kinetics were investigated. SEM images showed that both drug-free and drug-loaded nanofiber patches possess smooth and monodisperse structures, and nanofiber size increase occurred as the amount of drug increased. The tensile test results showed that the mechanical strength decreased as the drug was loaded. According to the drug release results, CA release ended at the 96th hour, while GEN release continued until the 264th hour. The antibacterial and antibiofilm activities of PVA/GEL, PVA/GEL/CA, PVA/GEL/GEN, and PVA/GEL/CA/GEN nanofiber patches against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated. Results showed that PVA/GEL/GEN and PVA/GEL/CA/GEN nanofiber patches have excellent antibacterial and antibiofilm activities. Moreover, all materials were biocompatible, with no cytotoxic effects in the mammalian cell model for 8 days. PVA/GEL/GEN nanofiber patches were the most promising material for a high cell survival ratio, which was confirmed by SEM images. This research aims to develop an alternative method to stop and treat the rapid progression of bacterial keratitis.

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“…N–H bending is seen at ∼1525 cm –1 . The peak at ∼1626 cm –1 indicates the C–O stretching . In Figure A,b, absorption peaks of pure PVA are shown.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Morphology Of the Nanofibrous Patchesmentioning

confidence: 99%

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