A novel study on the immunomodulatory effect of umbilical cord derived mesenchymal stem cells pretreated with traditional Chinese medicine Asarinin

He, Haiping; Yang, Tonghua; Fan, Li; Zhang, Lihua; Ling, Xiaosui

doi:10.1016/j.intimp.2021.108054

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…[77,78] Sesamin (NuBBE ID: 1416) has been studied in treating asthma, Parkinson's and Alzheimer's diseases, and several types of cancers, including breast, cervical, gallbladder and colon cancer. [79][80][81][82][83][84][85] In drug discovery and development process pharmacokinetics plays a vital role to explore lead compounds through optimizing their ADMET properties. In order to pass clinical trials subsequently the final approval of drug candidate, pharmacokinetic properties of the drug candidate and pharmacological action on the body, organ and tissue must be determined.…”

Section: Discussionmentioning

confidence: 99%

Amazon Plant‐Derived Compounds Suppressing Dengue NS5 Protein: Insights from Computational Drug Development and Network Pharmacology Approach

Ahmed,

Bari,

Biswas

et al. 2024

ChemistrySelect

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Dengue, a life‐threatening Flavivirus infection, is rampant across 128 tropical and subtropical regions, annually afflicting millions and causing 20,000 deaths due to inadequate treatments. Despite the FDA‐approved Dengvaxia vaccine, its limitations necessitate novel drug development. Notably, the enzymatic nature of the NS5 protein (PDB ID: 3p97) within DENV, responsible for viral RNA synthesis, makes it a prime drug target. Employing Pharmacoinformatics, Molecular Dynamics Simulations, Quantum Mechanics, and network pharmacology, we screened compounds from NuBBE, the Brazilian Amazon Plant Database, along with reported dengue compounds. Docking yielded promising scores (−11.1 to −2.8) and (−11 to −3.1) kcal/mol, respectively. From 1310 phytochemicals, top compounds emerged: Ramosin, Pectolinarin, hinokinin, and sesamin, boasting scores of −11, −11, −9.7, and −9.6, surpassing Acetaminophen's −5.8. Validated post‐docking interactions used 100 ns Molecular Dynamics Simulations and quantum mechanics. Pharmacokinetics and Toxicity analysis aligned with ADME norms, showing no undue toxicity. Network pharmacology unveiled connections between bioactive chemicals and disease targets. This investigation uncovers the potential of these compounds to inhibit DENV‐3 NS5 protein. In vitro, in vivo, and cell line assays are crucial next steps for specific anti‐dengue drug development.

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Section: Discussionmentioning

confidence: 99%

Amazon Plant‐Derived Compounds Suppressing Dengue NS5 Protein: Insights from Computational Drug Development and Network Pharmacology Approach

Ahmed,

Bari,

Biswas

et al. 2024

ChemistrySelect

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show abstract

“…[Fabaceae], caused ALF as well ( Li et al, 2019b ). Moreover, pre-treatment of umbilical cord-derived mesenchymal stem cells (UC-MSCs) with asarinin significantly promotes the immunosuppressive effects of MSC after HSC transplantation ( He et al, 2021 ), whereas it may have multiple cytotoxic effects, including arrhythmia, respiratory center depression, hepatotoxicity, and nephrotoxicity ( Jeong et al, 2018 ). These are Chinese medicines commonly used in the clinical practice of MI; thus, attention must be paid when using these botanical drugs.…”

Section: Deficiencies Of Chinese Medicines In Stem Cell Therapymentioning

confidence: 99%

Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction

Wang

Xue²,

Guo³

2022

Front. Pharmacol.

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Cardiovascular diseases are the leading cause of global mortality, in which myocardial infarction accounts for 46% of total deaths. Although good progress has been achieved in medication and interventional techniques, a proven method to repair the damaged myocardium has not yet been determined. Stem cell therapy for damaged myocardial repair has evolved into a promising treatment for ischemic heart disease. However, low retention and poor survival of the injected stem cells are the major obstacles to achieving the intended therapeutic effects. Chinese botanical and other natural drug substances are a rich source of effective treatment for various diseases. As such, numerous studies have revealed the role of Chinese medicine in stem cell therapy for myocardial infarction treatment, including promoting proliferation, survival, migration, angiogenesis, and differentiation of stem cells. Here, we discuss the potential and limitations of stem cell therapy, as well as the regulatory mechanism of Chinese medicines underlying stem cell therapy. We focus on the evidence from pre-clinical trials and clinical practices, and based on traditional Chinese medicine theories, we further summarize the mechanisms of Chinese medicine treatment in stem cell therapy by the commonly used prescriptions. Despite the pre-clinical evidence showing that traditional Chinese medicine is helpful in stem cell therapy, there are still some limitations of traditional Chinese medicine therapy. We also systematically assess the detailed experimental design and reliability of included pharmacological research in our review. Strictly controlled animal models with multi-perspective pharmacokinetic profiles and high-grade clinical evidence with multi-disciplinary efforts are highly demanded in the future.

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“…Salvia miltiorrhiza , a pivotal natural medicine, tanshinone IIA (TIIA) as its principal fat-soluble constituent. Modern pharmacological investigations have elucidated the anti-inflammatory and antioxidant properties of TIIA [ 13 , 14 ]. Our research revealed that pretreatment of MSC with TIIA, which is rooted in traditional Chinese medicine, augments their therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of tanshinone IIA-modified mesenchymal stem cells in a lipopolysaccharide-induced neuroinflammation model

Wu,

Chen,

et al. 2024

Heliyon

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A novel study on the immunomodulatory effect of umbilical cord derived mesenchymal stem cells pretreated with traditional Chinese medicine Asarinin

Cited by 11 publications

References 22 publications

Amazon Plant‐Derived Compounds Suppressing Dengue NS5 Protein: Insights from Computational Drug Development and Network Pharmacology Approach

Amazon Plant‐Derived Compounds Suppressing Dengue NS5 Protein: Insights from Computational Drug Development and Network Pharmacology Approach

Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction

Neuroprotective effect of tanshinone IIA-modified mesenchymal stem cells in a lipopolysaccharide-induced neuroinflammation model

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