A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

“…The key to develop MMC lies in the improvement of stationary phases with mixed-mode or multiple interactions. So far, two or more than two modes stationary phases have been reported, such as reversed-phase liquid chromatography (RPLC)/hydrophilic interaction chromatography (HILIC) [4][5][6], RPLC/ion-exchange chromatography (IEC) [7][8][9], HIILC/IEC [10,11], RPLC/HIILC/IEC [12,13], etc. However, the literatures of HIILC/IEC mixed-mode stationary phase are relatively less.…”

Versatile ligands for high-performance liquid chromatography: An overview of ionic liquid-functionalized stationary phases

“…A piece of innovative work by Qiao et al reported the preparation of HILIC SP using glucaminium cation [109]. From the sense of chemical structure, this new class of ILs belonged to ammonium salts functionalized by glucosyl unit.…”

Glucaminium ionic liquid-functionalized stationary phase for the separation of nucleosides in hydrophilic interaction chromatography

“…The glucose segment of glucaminium is of high hydrophilicity, enabling that glucaminium-based stationary phase can be used in hydrophilic interaction liquid chromatography (HILIC). Up to date, there is only one report on glucaminium stationary phase prepared via Bthiol-ene^click reaction [25]. The combination of ammonium and glucose imparted the new stationary phase flexible selectivity and multimodal behaviors, whereby reasonable retention and good separation efficiency toward flavonoids and nucleotides were realized [25].…”