A novel synergistic anticancer effect of fungal cholestanol glucoside and paclitaxel: Apoptosis induced by an intrinsic pathway through ROS generation in cervical cancer cell line (HeLa)

Subramaniam, Yogeswari; Kamalraj, Subban; Jayabaskaran, Chelliah

doi:10.1016/j.tiv.2021.105079

Cited by 13 publications

(8 citation statements)

References 39 publications

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“…Hydrogen peroxide (H 2 O 2 ) is one of the most important inducers of apoptosis ( Clément et al, 1998 ). Anticancer compounds have been shown to promote apoptosis via ROS production ( Tables 1 , 2 ) in a number of investigations ( Kopustinskiene et al, 2020 ; Perillo et al, 2020 ; Khan et al, 2021 ; Subramaniam et al, 2021 ). For example, in PC-3 (prostate cancer), HepG2 (hepatic cancer), and MCF-7 (breast cancer) cells, the polyphenol resveratrol was found to cause mitochondrial H 2 O 2 buildup by regulating antioxidant enzymes, resulting in apoptosis ( Khan et al, 2013 ).…”

Section: Role Of Reactive Oxygen Species In Cancer Cell Deathmentioning

confidence: 99%

Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications

Farhan

Rizvi

2022

Front. Pharmacol.

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Plant derived polyphenolic compounds are considered critical components of human nutrition and have shown chemotherapeutic effects against a number of malignancies. Several studies have confirmed the ability of polyphenols to induce apoptosis and regression of tumours in animal models. However, the mechanism through which polyphenols modulate their malignant cell selective anticancer effects has not been clearly established. While it is believed that the antioxidant properties of these molecules may contribute to lowering the risk of cancer induction by causing oxidative damage to DNA, it could not be held responsible for chemotherapeutic properties and apoptosis induction. It is a well known fact that cellular copper increases within the malignant cell and in serum of patients harboring malignancies. This phenomenon is independent of the cellular origin of malignancies. Based on our own observations and those of others; over the last 30 years our laboratory has shown that cellular copper reacts with plant derived polyphenolic compounds, by a Fenton like reaction, which generates reactive oxygen species and leads to genomic DNA damage. This damage then causes an apoptosis like cell death of malignant cells, while sparing normal cells. This communication reviews our work in this area and lays the basis for understanding how plant derived polyphenols can behave as prooxidants (and not antioxidants) within the microenvironment of a malignancy (elevated copper levels) and gives rationale for their preferential cytotoxicity towards malignant cells.

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Section: Role Of Reactive Oxygen Species In Cancer Cell Deathmentioning

confidence: 99%

Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications

Farhan

Rizvi

2022

Front. Pharmacol.

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“…viruses) on cervical cancer, which may be a direction worth exploring. In recent years, some reports have also found that they may affect the progression of cervical cancer (Liang et al, 2019;Stelzle et al, 2021;Subramaniam et al, 2021).…”

Section: Chlamydia Trachomatismentioning

confidence: 99%

“…There is a lack of studies on the effect of non-bacterial components ( Chlamydia , Mycoplasma , fungal , and non-HPV viruses) on cervical cancer, which may be a direction worth exploring. In recent years, some reports have also found that they may affect the progression of cervical cancer ( Liang et al, 2019 ; Stelzle et al, 2021 ; Subramaniam et al, 2021 ).…”

Section: The Driving Effects Of Microbiome On Cervical Cancermentioning

confidence: 99%

From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

et al. 2021

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Cervical cancer is the third leading cause of cancer-related death worldwide. Microbes and hosts form a mutually beneficial symbiosis relationship, and various parts of the host body are microbial habitats. Microbes can trigger inflammation in certain parts of the host body, contributing to cervical cancer development. This article reviews the relationship between cervicovaginal microbes, inflammation and cervical cancer, and discusses the effect of some key cervical microbes on cervical cancer. Finally, probiotic therapy and immunotherapy are summarized.

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“…These results suggested that NAC blocked the effect of ROS on gastric cancer cells, indicating that ROS triggered cell death through DR5-mediated mitochondrial apoptosis pathway (31). ROS are the key molecules in the process of apoptosis (32,33). It is reported that moderate level of ROS can increase the ability of cell survival (34).…”

Section: Discussionmentioning

confidence: 85%

LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells

Wang

Wu²,

Yu³

et al. 2021

Front. Oncol.

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Gastric cancer is a global health problem. In this study, we investigate the role of a novel Indole derivative, named LCT-3d, in inhibiting the growth of gastric cancer cells by MTT assay. The Western blotting results showed that LCT-3d modulated the mitochondrial-related proteins and Cleaved-Caspases 3/9, to induce cell apoptosis. The up-regulation of Death receptor 5 (DR5) in MGC803 cells was observed with LCT-3d treatment. Knockdown of DR5 on MGC803 cells partially reversed the LCT-3d-induced mitochondrial apoptosis. The level of Reactive Oxygen Species (ROS) in MGC803 cells was increased with LCT-3d treatment and could be blocked with the pretreatment of the ROS inhibitor N-Acetylcysteine (NAC). The results demonstrate that the elevating ROS can up-regulate the expression of DR5, resulting in apoptosis via mitochondrial pathway. Although the nuclear factor erythroid-2 related factor 2 (Nrf2) pathway served an important role in protecting gastric cancer cells against the injury of ROS, it can’t reverse LCT-3d-induced cell apoptosis. Taken together, our study showed that LCT-3d induced apoptosis via DR5-mediated mitochondrial apoptotic pathway in gastric cancer cells. LCT-3d could be a novel lead compound for development of anti-cancer activity in gastric cancer.

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A novel synergistic anticancer effect of fungal cholestanol glucoside and paclitaxel: Apoptosis induced by an intrinsic pathway through ROS generation in cervical cancer cell line (HeLa)

Cited by 13 publications

References 39 publications

Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications

Understanding the Prooxidant Action of Plant Polyphenols in the Cellular Microenvironment of Malignant Cells: Role of Copper and Therapeutic Implications

From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells

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