A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma

Geng, Yiting; Zhu, Dan-Xia; Wu, Chen; Wu, Jun; Wang, Qi; Li, Ruiqi; Jiang, Jingting

doi:10.1016/j.intimp.2018.10.002

Cited by 121 publications

(127 citation statements)

References 30 publications

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“…A limited number of studies have been published analyzing the prognostic capacity of SIRI. [27][28][29][30][31] To the best of our knowledge, this is the first study analyzing SIRI as a prognostic factor in a large series of OSCC.…”

Section: Discussionmentioning

confidence: 91%

“…We agree with Qi et al that incorporating the prognostic value added by each leukocyte count creates an even more integrative biomarker than analyzing the individual counts. A limited number of studies have been published analyzing the prognostic capacity of SIRI . To the best of our knowledge, this is the first study analyzing SIRI as a prognostic factor in a large series of OSCC.…”

Section: Discussionmentioning

confidence: 96%

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Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer

Valero

Zanoni

McGill

et al. 2019

Cancer

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Background Inflammation and immune surveillance evasion are cancer hallmarks. Peripheral blood leukocytes (PBLs) represent both. The aim of the current study was to examine PBLs as predictors of outcomes in oral cavity squamous cell carcinoma (OSCC), and to find specific cutoffs with the goal of including PBLs as host factor in patients' preoperative risk assessment. Methods Previously established head and neck squamous cell carcinoma (HNSCC) cutoffs were examined in an independent cohort of 1369 OSCC patients. Then optimal OSCC cutoffs were found and validated in the subset of patients with OSCC (n = 119) from the external HNSCC cohort. The PBLs analyzed were neutrophils, monocytes, and lymphocytes individually, the neutrophil‐to‐lymphocyte ratio (NLR), and a combined index using all PBLs called Systemic Inflammation Response Index (SIRI). Results All parameters were significant predictors of survival using the previous cutoffs. However, OSCC cutoffs stratified survival outcomes better. Considering neutrophils ≤4.8 × 109/L as reference, patients with 4.8–9.1 × 109/L neutrophils had 1.536 times higher risk of death (95% CI, 1.295‐1.822), and patients with ≥9.1 × 109/L had 3.076 times higher risk (95% CI: 2.170‐4.360). All PBLs maintained independent prognostic capacity in multivariable analysis. Neutrophils, NLR, and SIRI were significant predictors of survival when validating OSCC cutoffs in the external validation cohort. Conclusions Pretreatment peripheral blood neutrophils, NLR, and SIRI are the most robust independent predictors of overall survival among all PBLs in OSCC. The authors report externally validated cutoffs that demonstrate the feasibility of including PBLs as host features in the preoperative prognostication of OSCC.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer

Valero

Zanoni

McGill

et al. 2019

Cancer

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“…This scoring system was established to reflect patients' systemic inflammatory response and sensitivity to chemotherapeutic agents . Since its first introduction onto prognostic prediction, the clinical significance of SIRI has been validated across a variety of malignancies …”

Section: Discussionmentioning

confidence: 99%

“…Recently, a novel inflammatory indicator comprising continuous variables of peripheral neutrophil, lymphocyte and monocyte counts, termed systemic inflammation response index (SIRI), was first developed on patients receiving chemotherapy for advanced pancreatic cancer, showing a potent prognostic significance . SIRI was then reported to be an excellent predictor for long‐term survival of patients with oesophageal squamous cell carcinoma, gastric adenocarcinoma and renal cell carcinoma . However, until recently, there has been no study addressing on clinical significance of SIRI for either short‐term or long‐term outcome following lung cancer surgery.…”

Section: Introductionmentioning

confidence: 99%

“…5 SIRI was then reported to be an excellent predictor for long-term survival of patients with oesophageal squamous cell carcinoma, gastric adenocarcinoma and renal cell carcinoma. [6][7][8][9] However, until recently, there has been no study addressing on clinical significance of SIRI for either short-term or long-term outcome following lung cancer surgery.…”

Section: Introduction Rationalementioning

confidence: 99%

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Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Zhang

et al. 2019

ANZ Journal of Surgery

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Background Our propensity score‐matching (PSM) study evaluated the prognostic significance of systemic inflammation response index (SIRI) for patients undergoing video‐assisted thoracoscopic surgery lobectomy for non‐small‐cell lung cancer (NSCLC). Methods This study was conducted on prospectively maintained database in our institution between December 2013 and March 2015. Pre‐operative SIRI was calculated by peripheral monocyte × neutrophil/lymphocyte counts. Survival analysis was performed to distinguish differences in post‐operative survival between patients stratified by an optimum cut‐off of SIRI. Multivariable Cox proportional hazards regression models were established to determine independent prognostic factors. Results There were 390 patients with resected NSCLC included. A SIRI of 0.99 was identified as the optimum cut‐off regarding to post‐operative survival. Both overall survival (OS) and disease‐free survival (DFS) in patients with SIRI >0.99 were significantly shortened than those in patient with SIRI ≤0.99. Patients with SIRI >0.99 had significantly lower rates of OS and DFS compared to those patients with SIRI ≤0.99. These differences still remained significant after subgroup analyses and PSM analyses. Multivariable analyses on the entire cohort and the PSM cohort commonly demonstrated that high pre‐operative SIRI could be an independent prognostic factor for unfavourable OS and DFS of NSCLC. Conclusions SIRI serves as a novel risk stratification tool to refine prognostic prediction for surgically resected NSCLC. SIRI may help surgeons to screen high‐surgical‐risk patients and formulate individualized treatment schemes.

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Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke

et al. 2022

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Objectives Inflammation plays an essential role in acute ischemic stroke (AIS). Recent studies have recognized the systemic inflammation response index (SIRI) as a useful index to indicate inflammation status and predict the prognosis of multiple diseases. However, the relationship between SIRI and AIS prognosis is unclear. Our study is aimed to investigate the association between SIRI and the prognosis of AIS. Methods Our study prospectively recruited 287 consecutive patients with first‐ever stroke within 72 h after stroke. Demographic and clinical information was collected at baseline. The functional prognosis was assessed 3 months after AIS using the modified Rankin Scale (mRS). A poor outcome was defined as mRS > 2. SIRI was calculated as neutrophil × monocyte/lymphocyte count. Univariate and multivariate analyses were introduced to identify the association between SIRI and AIS prognosis. Receiver operating characteristic curve and reclassification analyses were used to evaluate the predictive value of SIRI for AIS prognosis. Results The patients with poor prognosis account for 27.5% of all participants. After fully adjusting for all covariates, each standard deviation increment of SIRI caused 58.9% additional risk for poor prognosis after AIS. When dividing SIRI into quartiles, the fourth quartile had a 6.152 times risk than the first quartile. Moreover, after adding SIRI into established clinical risk factors, AUC showed a significant improvement (0.829 vs. 0.790, p for comparison = .016). Consistently, category‐free net reclassification index (NRI, 0.761, 95% CI: 0.517–1.004, p < .001) and integrated discrimination index (IDI, 0.093, 95% CI: 0.0512–0.134, p < .001) confirmed the improvement by SIRI to predict poor prognosis of AIS, Conclusion SIRI is an independent prognostic indicator for AIS. Elevated SIRI is associated with poor functional outcome of AIS. Our findings suggest the usefulness of SIRI to refine the risk stratification of unfavorable prognosis of AIS.

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A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma

Cited by 121 publications

References 30 publications

Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer

Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer

Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke

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