A novel tailed primer nucleic acid test for detection of HPV 16, 18 and 45 DNA at the point of care
Megan M. Chang,
Ariel Ma,
Emilie Newsham Novak
et al.
Abstract:Cervical cancer is a leading cause of death for women in low-resource settings despite being preventable through human papillomavirus (HPV) vaccination, early detection, and treatment of precancerous lesions. The World Health Organization recommends high-risk HPV (hrHPV) as the preferred cervical cancer screening strategy, which is difficult to implement in low-resource settings due to high costs, reliance on centralized laboratory infrastructure, and long sample-to-answer times. To help meet the need for rapi… Show more
We describe the optimization and pilot clinical validation of an isothermal reaction with lateral flow readout capable of detecting multiple pathologic point mutations in the human β-globin gene responsible for the majority of sickle cell disease.
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