A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis

Elbay, Ahmet; Özer, Ömer Faruk; Altınışık, Muhammed; Elbay, Arif Emre; Sezer, Taha; Bayraktar, Havvanur; Özdemir, Hakan

doi:10.1080/00365513.2017.1292539

Cited by 11 publications

(12 citation statements)

References 23 publications

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“…All the studies, except one [72], were carried out in Turkey in a variety of age groups and clinical situations since 2015. The thiols can be measured in serum/plasma, but semen sample [72] and aqueous humor [73] also have been used, and they are applicable to evaluate the oxidative state in a variety of clinical events, from alterations during pregnancy, cardiovascular, psychiatric, neurological, hereditary, infectious diseases, etc. Although the information is abundant, the analysis result has not shown substantial differences among the studies, because all agree in recommending the thiol ratios to their use in clinical events; therefore, we only did a descriptive analysis of the information (Table 5) and presented references found in a supplementary file in case of any reader is interested in consulting the information.…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Sánchez-Rodrı́guez

Mendoza-Núñez

2019

Oxidative Medicine and Cellular Longevity

111

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Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor of oxidants, that causes aging and disease. Many studies have been published that demonstrate the relationship between OS and human health and disease; however, the following questions arise: (i) how are we sure that the OS is present in a biological process? (ii) Is the OS reported in the different investigations equivalent? (iii) What are the best oxidant and antioxidant markers for OS diagnosis? (iv) Can we establish the types and the intensity of the OS? (v) Does OS index could be useful for research and/or application in clinical medicine? In this regard, several indexes have been proposed to measure OS in humans relative to the state of health and disease, among which the following can be highlighted: Oxidative Stress Index (OSI), Tiol Ratios (-SH/TT, -SS/-SH, and-SS/TT), Glutathione Ratio (GSSG/GSH), Oxidative Stress Score (OSS), and OXY-index. Therefore, the aim of this review is to present the state of the art of knowledge about OS indexes for diagnosis of health or disease in humans. We searched for articles in English or Spanish in the PubMed/MEDLINE and Scopus electronic databases published up until May 2019. The keywords used were “oxidative stress,” “index,” and “oxidative stress index.” It was identified 11479 records in both databases, and 490 articles were analyzed. Our review suggests that all indexes analyzed allow diagnose and differentiate the OS related to human health and disease. Also, the studies on OSI, Oxy-score, and OSS indexes have proven to be reliable, practical, and with clinical utility. However, it is necessary to continue with longitudinal studies, especially assess the usefulness of the indexes in the clinical prognosis, and make comparative studies between the different indexes.

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Section: Resultsmentioning

confidence: 99%

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Sánchez-Rodrı́guez

Mendoza-Núñez

2019

Oxidative Medicine and Cellular Longevity

111

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“…They contain a sulfhydryl group which can transform into disulfide bonds when oxidized by the oxygen molecules. This reaction is reversible, so the disulfide bonds can turn back into thiols [ 92 ]. The chemical versatility allows them to participate in different processes like signalling, antioxidant defence, and structural stabilization [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Andreicut

Pârvu

Moţ

et al. 2018

Oxidative Medicine and Cellular Longevity

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Oxidative stress and inflammation are interlinked processes. The aim of the study was to perform a phytochemical analysis and to evaluate the antioxidant and anti-inflammatory activities of ethanolic Mahonia aquifolium flower (MF), green fruit (MGF), and ripe fruit (MRF) extracts. Plant extract chemical composition was evaluated by HLPC. A DPPH test was used for the in vitro antioxidant activity. The in vivo antioxidant effects and the anti-inflammatory potential were tested on a rat turpentine oil-induced inflammation, by measuring serum nitric oxide (NOx) and TNF-alpha, total oxidative status (TOS), total antioxidant reactivity (TAR), oxidative stress index (OSI), 3-nitrothyrosine (3NT), malondialdehyde (MDA), and total thiols (SH). Extracts were administrated orally in three dilutions (100%, 50%, and 25%) for seven days prior to inflammation. The effects were compared to diclofenac. The HPLC polyphenol and alkaloid analysis revealed chlorogenic acid as the most abundant compound. All extracts had a good in vitro antioxidant activity, decreased NOx, TOS, and 3NT, and increased SH. TNF-alpha was reduced, and TAR increased only by MF and MGF. MDA was not influenced. Our findings suggest that M. aquifolium has anti-inflammatory and antioxidant effects that support the use in primary prevention of the inflammatory processes.

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“…Thiols are important determinants of total antioxidant capacity . Thiol groups of proteins are converted to disulfide bonds when oxidized with oxygen molecules in the medium . Thiol groups such as CyS/CySS, mercaptalbumin, glutathione, and thioredoxin‐1 and ‐2 are key factors in antioxidants and are associated with various diseases .…”

Section: Discussionmentioning

confidence: 99%

Plasma Cystine Levels and Cardiovascular and All‐Cause Mortality in Hemodialysis Patients

et al. 2018

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Oxidative stress accelerates the development of cardiovascular disease. Plasma cystine, a thiol oxidative stress marker, is related to several established factors for cardiovascular disease risk and prognosis. Although a comprehensive oxidative stress index is clinically required for hemodialysis patients with high oxidative stress, there are few reports concerning thiol oxidative stress markers predicting their prognosis. We investigated the relationship between plasma amino acids including cystine levels and cardiovascular disease-related and all-cause mortality in 132 maintenance hemodialysis patients. Higher cystine levels were associated with old age, longer hemodialysis duration, hemodialysis-associated hypotension, higher cardiothoracic ratio, higher blood urea nitrogen, and lower ankle-brachial index. Multivariate Cox regression analysis revealed that high plasma cystine was independently related with both cardiovascular disease mortality and all-cause mortality. Thus, high plasma cystine levels predict the prognosis of hemodialysis patients. High cystine levels necessitate a careful investigation for the cause of oxidative stress and comorbidities like vascular injury.

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A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis

Cited by 11 publications

References 23 publications

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Plasma Cystine Levels and Cardiovascular and All‐Cause Mortality in Hemodialysis Patients

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