A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch

Papoiu, Alexandru D.P.; Valdés‐Rodríguez, Rodrigo; Nattkemper, Leigh; Chan, Yiong Huak; Hahn, Gary; Yosipovitch, Gil

doi:10.2340/00015555-1564

Cited by 44 publications

(35 citation statements)

References 32 publications

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“…Topical strontium in a 4 % formulation was recently shown in one double-blind, vehicle-controlled trial to be effective in reducing both the duration and the peak intensity of experimentally induced itch in humans [137]. Strontium can be used therapeutically for itch secondary to xerosis, NE or LSC.…”

Section: Topical Treatmentsmentioning

confidence: 99%

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

2015

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Chronic itch in the elderly is a common problem, with a significant impact on quality of life and sleep in elderly patients. Chronic itch may be attributable to several causes, including dry skin, immunosenescence and neural degeneration. Itch may also be caused by skin diseases, such as seborrhoeic dermatitis and stasis dermatitis; systemic conditions, such as end-stage renal disease and diabetes; and psychogenic conditions, such as depression and anxiety. The use of polypharmacy may also cause itch, with or without a rash. Specifically, thiazides and calcium channel blockers have been known to cause itch in elderly patients. Management should be tailored according to the underlying dermatological or systemic aetiology of itch. Topical treatment is the mainstay of therapy, providing special emphasis on skin hydration and barrier repair. In addition, topical and oral medications that target the nervous system and reduce neuronal hypersensitization, such as gabapentin and selective antidepressants, have a role in treating patients with severe chronic itch. Furthermore, management must account for changes in metabolism and pharmacokinetics of drugs in the aging population in order to prevent the occurrence of adverse effects.

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Section: Topical Treatmentsmentioning

confidence: 99%

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

2015

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“…Papoiu et al . showed that the strontium chloride formulation was superior to hydrocortisone on the peak of skin itch intensity (32). So the strontium chloride was considered as positive control.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 56 healthy human volunteers (36 men and 20 women, aged 26-44 years) in 2 groups of 28 volunteers each were recruited and written consent was obtained from all subjects. Volunteers were factory workers recruited from the Goltash Company with a self-reported history of “sensitive skin” and were sensitive to a prescreening lactic acid facial challenge (32). The study protocol was approved by the Ethics Committee of Isfahan University of Medical Sciences (ID No: IR.MUI.REC.93.3.378).…”

Section: Methodsmentioning

confidence: 99%

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Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans

et al. 2016

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Sensitive skin is a frequently mentioned cosmetic complaint. Addition of a biomimetic of neuromediator has recently appeared as a promising new way to cure skin care product problems. This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protective effect with that of the well-known anti irritant strontium chloride. The effect of each test compound was studied on 28 selected healthy volunteers with sensitive skin in accordance with a double-blind vehicle-controlled protocol. From day 1 to day 13 each group was applied the test compound (bPOMC or strontium chloride) to one wing of the nose and the corresponding placebo (vehicle) to the other side twice daily. On days 0 and 14, acute skin irritation was induced by capsaicin solution and quantified using clinical stinging test assessments. Following the application of capsaicin solution, sensory irritation was evaluated using a 4-point numeric scale. The sensations perceived before and after treatment (on days 0 and 14) was calculated for the two zones (test materials and vehicle). Ultimately the percentage of variation between each sample and the placebo and also the inhibitory effect of bPOMC compared to that of strontium chloride were reported. Clinical results showed that after two weeks treatment, the levels of skin comfort reported in the group treated with bPOMC were significantly higher than those obtained in the placebo group and the inhibitory effect of bPOMC was about 47% higher than that of strontium chloride. The results of the present study support the hypothesis that biomimetic peptides may be effective on sensitive skin.

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“…Topical strontium gel, a calcimimetic that blocks ion channels in nerves, has been shown in a double-blind study to inhibit itch induced by cowhage and histamine and has been used against different types of chronic itch (Zhai et al 2000b;Papoiu et al 2013).…”

Section: Miscellaneous Ion Channel Blockersmentioning

confidence: 99%

Current Topical and Systemic Therapies for Itch

Leslie

Greaves

Yosipovitch

2015

Handbook of Experimental Pharmacology

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Itch is a common distressing symptom which may be caused by multifactorial aetiologies including inflammatory skin diseases, systemic diseases, neuropathic conditions and psychogenic disorders. Itch is a term used synonymously with pruritus and is defined as acute if it lasts less than 6 weeks or chronic if it persists for more than 6 weeks. It can have the same impact on the quality of life as chronic pain and shares many of the same pathophysiological pathways. Depending on the aetiology of the itch, different pathogenic mechanisms have been postulated with a number of mediators identified. These include histamine, leukotrienes, proteases, neuropeptides, cytokines and opioids, which may activate peripheral itch-mediating C-fibres via receptors on the nerve terminals and central neuronal pathways. Therefore, there is no single universally effective anti-itch treatment available. First-line treatments for itch include topical therapies, such as emollients, mild cleansers (low pH), topical anaesthetics, steroids, calcineurin inhibitors and coolants (menthol). Treatment with systemic therapies can vary according to the aetiology of the chronic itch. Non-sedating antihistamines are helpful in conditions such as urticaria where the itch is primarily histamine mediated. Although the itch of eczema is not mediated by histamine, sedating antihistamines at night are helpful to break the itch-scratch cycle. Chronic itch may also be treated with other systemic therapies, such as anticonvulsants, antidepressants as well as mu-opioid antagonists, kappa-opioid agonists and phototherapy, depending on the cause of the itch. This article summarises the topical and systemic therapies available with our current understanding of the pathophysiology of itch.

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A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch

Cited by 44 publications

References 32 publications

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Chronic Pruritus in the Elderly: Pathophysiology, Diagnosis and Management

Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans

Current Topical and Systemic Therapies for Itch

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