A novel transient phase kinetic analysis of the fractional modification of monocyclic enzyme cascades

Masiá, M. Dolores; García-Moreno, Manuela; Garcı́a-Sevilla, Francisco; Escribano, Julio; Molina‐Alarcón, Milagros; Amo-Saus, Maria L.; Ortiz-Ruiz, Carmen Vanessa; Varón, R.

doi:10.1007/s10910-016-0659-y

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Their original motivation was to extend the parameter domain for the applicability of the standard QSSA (Segel and Slemrod, 1989). Later on, the conditions for the validity of the tQSSA have been refined (Schnell and Maini, 2000;Tzafriri, 2003), and the method has been successfully applied to more complicated reaction systems such as the reversible Michaelis-Menten reaction (Tzafriri and Edelman, 2004), substrate competition (Pedersen et al, 2007), covalent modification cycles (Gomez-Uribe et al, 2007;Ciliberto et al, 2007;Pedersen et al, 2010) and to describe the transient phase kinetics (Masia et al, 2016).…”

Section: High Enzyme Concentrationsmentioning

confidence: 99%

Analysis of network motifs in cellular regulation: Structural similarities, input–output relations and signal integration

Straube

2017

Biosystems

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Much of the complexity of regulatory networks derives from the necessity to integrate multiple signals and to avoid malfunction due to cross-talk or harmful perturbations. Hence, one may expect that the input-output behavior of larger networks is not necessarily more complex than that of smaller network motifs which suggests that both can, under certain conditions, be described by similar equations. In this review, we illustrate this approach by discussing the similarities that exist in the steady state descriptions of a simple bimolecular reaction, covalent modification cycles and bacterial two-component systems. Interestingly, in all three systems fundamental input-output characteristics such as thresholds, ultrasensitivity or concentration robustness are described by structurally similar equations. Depending on the system the meaning of the parameters can differ ranging from protein concentrations and affinity constants to complex parameter combinations which allows for a quantitative understanding of signal integration in these systems. We argue that this approach may also be extended to larger regulatory networks.

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Section: High Enzyme Concentrationsmentioning

confidence: 99%

Analysis of network motifs in cellular regulation: Structural similarities, input–output relations and signal integration

Straube

2017

Biosystems

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An efficient and fully explicit model to simulate delayed activator–inhibitor systems with anomalous diffusion

Macías‐Díaz

2019

J Math Chem

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A novel transient phase kinetic analysis of the fractional modification of monocyclic enzyme cascades

Cited by 2 publications

References 16 publications

Analysis of network motifs in cellular regulation: Structural similarities, input–output relations and signal integration

Analysis of network motifs in cellular regulation: Structural similarities, input–output relations and signal integration

An efficient and fully explicit model to simulate delayed activator–inhibitor systems with anomalous diffusion

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