A novel triple pump 1050 nm, 1400 nm, 800 nm pumping scheme for thulium doped fiber amplifier

Singh, Rajandeep; Singh, Maninder; Kaur, Baljeet

doi:10.1016/j.ijleo.2011.11.102

Cited by 15 publications

(7 citation statements)

References 3 publications

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“…The dissolution of NPs into toxic ions seems to be an important factor regarding the toxicity of the material [ 38 – 39 ]. Dissolution and therefore release of Zn 2+ ions in the culture medium has been already described for the ZnO-NPs used in the present study [ 40 ]. Moreover, the dissolution (50 to 60% within 24 h) of ZnO-NPs in cell culture medium facilitates an interaction of Zn 2+ ions with cells [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Hirn¹,

Haberl²,

Loza³

et al. 2014

Beilstein J. Nanotechnol.

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SummaryPrecision-cut lung slices (PCLS) are an established ex vivo alternative to in vivo experiments in pharmacotoxicology. The aim of this study was to evaluate the potential of PCLS as a tool in nanotoxicology studies. Silver (Ag-NPs) and zinc oxide (ZnO-NPs) nanoparticles as well as quartz particles were used because these materials have been previously shown in several in vitro and in vivo studies to induce a dose-dependent cytotoxic and inflammatory response. PCLS were exposed to three concentrations of 70 nm monodisperse polyvinylpyrrolidone (PVP)-coated Ag-NPs under submerged culture conditions in vitro. ZnO-NPs (NM110) served as ‘soluble’ and quartz particles (Min-U-Sil) as ‘non-soluble’ control particles. After 4 and 24 h, the cell viability and the release of proinflammatory cytokines was measured. In addition, multiphoton microscopy was employed to assess the localization of Ag-NPs in PCLS after 24 h of incubation. Exposure of PCLS to ZnO-NPs for 4 and 24 h resulted in a strong decrease in cell viability, while quartz particles had no cytotoxic effect. Moreover, only a slight cytotoxic response was detected by LDH release after incubation of PCLS with 20 or 30 µg/mL of Ag-NPs. Interestingly, none of the particles tested induced a proinflammatory response in PCLS. Finally, multiphoton microscopy revealed that the Ag-NP were predominantly localized at the cut surface and only to a much lower extent in the deeper layers of the PCLS. In summary, only ‘soluble’ ZnO-NPs elicited a strong cytotoxic response. Therefore, we suggest that the cytotoxic response in PCLS was caused by released Zn2+ ions rather than by the ZnO-NPs themselves. Moreover, Ag-NPs were predominantly localized at the cut surface of PCLS but not in deeper regions, indicating that the majority of the particles did not have the chance to interact with all cells present in the tissue slice. In conclusion, our findings suggest that PCLS may have some limitations when used for nanotoxicology studies. To strengthen this conclusion, however, other NP types and concentrations need to be tested in further studies.

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Section: Discussionmentioning

confidence: 99%

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Hirn¹,

Haberl²,

Loza³

et al. 2014

Beilstein J. Nanotechnol.

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“…The NMs used in these investigations are representative NMs from the JRC Repository and are indicated in Table . Each of these NMs originates from one batch of commercially manufactured NMs. , The details about their main physicochemical characteristics are described in the JRC Scientific and Technical Reports on NM-Series of Representative Manufactured Nanomaterials, − OECD Dossiers on NMs, − as well as in the recent publications. , …”

Section: Methodsmentioning

confidence: 99%

Thermodynamic Parameters at Bio–Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO₂, and TiO₂

Precupaş

Gheorghe

Botea‐Petcu

et al. 2020

Chem. Res. Toxicol.

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Understanding nanomaterial (NM)−protein interactions is a key issue in defining the bioreactivity of NMs with great impact for nanosafety. In the present work, the complex phenomena occurring at the bio/nano interface were evaluated in a simple case study focusing on NM−protein binding thermodynamics and protein stability for three representative metal oxide NMs, namely, zinc oxide (ZnO; NM-110), titanium dioxide (TiO 2 ; NM-101), and silica (SiO 2 ; NM-203). The thermodynamic signature associated with the NM interaction with an abundant protein occurring in most cell culture media, bovine serum albumin (BSA), has been investigated by isothermal titration and differential scanning calorimetry. Circular dichroism spectroscopy offers additional information concerning adsorption-induced protein conformational changes. The BSA adsorption onto NMs is enthalpy-controlled, with the enthalpic character (favorable interaction) decreasing as follows: ZnO (NM-110) > SiO 2 (NM-203) > TiO 2 (NM-101). The binding of BSA is spontaneous, as revealed by the negative free energy, ΔG, for all systems. The structural stability of the protein decreased as follows: TiO 2 (NM-101) > SiO 2 (NM-203) > ZnO (NM-110). As protein binding may alter NM reactivity and thus the toxicity, we furthermore assessed its putative influence on DNA damage, as well as on the expression of target genes for cell death (RIPK1, FAS) and oxidative stress (SOD1, SOD2, CAT, GSTK1) in the A549 human alveolar basal epithelial cell line. The enthalpic component of the BSA−NM interaction, corroborated with BSA structural stability, matched the ranking for the biological alterations, i.e., DNA strand breaks, oxidized DNA lesions, cell-death, and antioxidant gene expression in A549 cells. The relative and total content of BSA in the protein corona was determined using mass-spectrometry-based proteomics. For the present case study, the thermodynamic parameters at bio/nano interface emerge as key descriptors for the dominant contributions determining the adsorption processes and NMs toxicological effect.

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“…Table 2 shows some key characteristics of JRCNM02102a and JRCNM02101a reported by the JRC. 96 JRCNM02102a, in particular, has been studied extensively, including long-term inhalation studies; such studies are lacking for JRCNM02101a. JRCNM02102a is known to have a half-life >60 days.…”

Section: Demonstration Of Iatasmentioning

confidence: 99%

An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure

Braakhuis

Murphy

Ma‐Hock

et al. 2021

Applied In Vitro Toxicology

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Introduction: Here, we describe the generation of hypotheses for grouping nanoforms (NFs) after inhalation exposure and the tailored Integrated Approaches to Testing and Assessment (IATA) with which each specific hypothesis can be tested. This is part of a state-of-the-art framework to support the hypothesis-driven grouping and read-across of NFs, as developed by the EU-funded Horizon 2020 project GRACIOUS. Development of Grouping Hypotheses and IATA: Respirable NFs, depending on their physicochemical properties, may dissolve either in lung lining fluid or in acidic lysosomal fluid after uptake by cells. Alternatively, NFs may also persist in particulate form. Dissolution in the lung is, therefore, a decisive factor for the toxicokinetics of NFs. This has led to the development of four hypotheses, broadly grouping NFs as instantaneous, quickly, gradually, and very slowly dissolving NFs. For instantaneously dissolving NFs, hazard information can be derived by read-across from the ions. For quickly dissolving particles, as accumulation of particles is not expected, ion toxicity will drive the toxic profile. However, the particle aspect influences the location of the ion release. For gradually dissolving and very slowly dissolving NFs, particle-driven toxicity is of concern. These NFs may be grouped by their reactivity and inflammation potency. The hypotheses are substantiated by a tailored IATA, which describes the minimum information and laboratory assessments of NFs under investigation required to justify grouping. Conclusion:The GRACIOUS hypotheses and tailored IATA for respiratory toxicity of inhaled NFs can be used to support decision making regarding Safe(r)-by-Design product development or adoption of precautionary measures to mitigate potential risks. It can also be used to support read-across of adverse effects such as pulmonary inflammation and subsequent downstream effects such as lung fibrosis and lung tumor formation after long-term exposure.

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A novel triple pump 1050 nm, 1400 nm, 800 nm pumping scheme for thulium doped fiber amplifier

Cited by 15 publications

References 3 publications

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Thermodynamic Parameters at Bio–Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO₂, and TiO₂

An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure

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A novel triple pump 1050 nm, 1400 nm, 800 nm pumping scheme for thulium doped fiber amplifier

Cited by 15 publications

References 3 publications

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

Thermodynamic Parameters at Bio–Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO2, and TiO2

An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure

Contact Info

Product

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Thermodynamic Parameters at Bio–Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO₂, and TiO₂