A novel two-dimensional quantitative shear wave elastography to make differential diagnosis of breast lesions: Comprehensive evaluation and influencing factors

Yao, Meicun; Wu, Rong; Xu, Gelin; Zhao, Liang; Liu, Hui; Pu, Huan; Fang, Yan

doi:10.3233/ch-16188

Cited by 13 publications

(4 citation statements)

References 26 publications

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“…First, the intra-operator and inter-operator consistency of quantitative shear wave speed measurements and QSWP were not assessed in our study. Previous studies showed that shear wave measurements were highly reproducible for assessing breast lesions and thus observer variability is not expected to have large influence on this study 23 , 24 . Second, only patients and lesions factors were evaluated for association with shear wave propagation quality, while equipment related factors (such as thermal noise, finite signal bandwidth, and the geometric spreading and absorbing of shear waves) were no studied 25 .…”

Section: Discussionmentioning

confidence: 97%

Value of shear wave arrival time contour display in shear wave elastography for breast masses diagnosis

Zhou

Wang

Ren

et al. 2017

Sci Rep

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To evaluate the diagnostic performance of shear wave arrival time contour (SWATC) display for the diagnosis of breast lesions and to identify factors associated with the quality of shear wave propagation (QSWP) in breast lesions. This study included 277 pathologically confirmed breast lesions. Conventional B-mode ultrasound characteristics and shear wave elastography parameters were computed. Using the SWATC display, the QSWP of each lesion was assigned to a two-point scale: score 1 (low quality) and score 2 (high quality). Binary logistic regression analysis was performed to identify factors associated with QSWP. The area under the receiver operating characteristic curve (AUROC) for QSWP to differentiate benign from malignant lesions was 0.913, with a sensitivity of 91.9%, a specificity of 90.7%, a positive predictive value (PPV) of 74.0%, and a negative predictive value (NPV) of 97.5%. Compared with using the standard deviation of shear wave speed (SWSSD) alone, SWSSD combined with QSWP increased the sensitivity from 75.8% to 93.5%, but decreased the specificity from 95.8% to 89.3% (P < 0.05). SWSSD was identified to be the strongest factor associated with the QSWP, followed by tumor malignancy and the depth of the lesion. In conclusion, SWATC display may be useful for characterization of breast lesions.

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Section: Discussionmentioning

confidence: 97%

Value of shear wave arrival time contour display in shear wave elastography for breast masses diagnosis

Zhou

Wang

Ren

et al. 2017

Sci Rep

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“…In our experience, using the most recent reconstruction algorithm (Virtual Touch IQ–VTIQ) and very low precompression (to avoid artificial tissue stiffening), a cut-off value of 3.23 m/s shows a high area under the receiver operating characteristic (ROC) curve of 0.853 [ 22 ]. Other studies using VTIQ proposed in part similar, in part different cut-off values [ 23 , 24 ]. It is evident that more standardization is necessary, especially regarding the degree of precompression applied.…”

Section: Acoustic Radiation Force Impulse Imagingmentioning

confidence: 99%

New diagnostic tools for breast cancer

Baltzer

Kapetas

Marino

et al. 2017

memo

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SummaryImaging plays a major role in the diagnosis, treatment, and follow-up of breast cancer. Findings that require further assessment will be detected both at screening and curative mammography. Most findings that are further worked up tend to yield benign diagnoses. Consequently, there is an ongoing search for new tools to reduce recalls and unnecessary biopsies while maintaining or improving cancer detection rates. The clinically most promising methods in this respect are described and discussed in this review.

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“…Recently, shear wave elastography (SWE), a specific ultrasound technique to quantify the stiffness of a lesion on imaging, showed promising results to reduce the number of unnecessary biopsies in some pilot trials [4][5][6][7][8][9][10][11] and one prospective multicenter trial [12]. SWE quantifies the stiffness of a lesion by evaluating the propagating speed of shear waves through the tissuethe output measurement is given either in meters per second (m/s) or kilopascals [13].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Shear Wave Elastography to Reduce Unnecessary Biopsies in Breast Cancer Diagnosis: An International, Diagnostic, Multicenter Trial

et al. 2021

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Purpose In this prospective, multicenter trial we evaluated whether additional shear wave elastography (SWE) for patients with BI-RADS 3 or 4 lesions on breast ultrasound could further refine the assessment with B-mode breast ultrasound for breast cancer diagnosis. Materials and Methods We analyzed prospective, multicenter, international data from 1288 women with breast lesions rated by conventional 2 D B-mode ultrasound as BI-RADS 3 to 4c and undergoing 2D-SWE. After reclassification with SWE the proportion of undetected malignancies should be < 2 %. All patients underwent histopathologic evaluation (reference standard). Results Histopathologic evaluation showed malignancy in 368 of 1288 lesions (28.6 %). The assessment with B-mode breast ultrasound resulted in 1.39 % (6 of 431) undetected malignancies (malignant lesions in BI-RADS 3) and 53.80 % (495 of 920) unnecessary biopsies (biopsies in benign lesions). Re-classifying BI-RADS 4a patients with a SWE cutoff of 2.55 m/s resulted in 1.98 % (11 of 556) undetected malignancies and a reduction of 24.24 % (375 vs. 495) of unnecessary biopsies. Conclusion A SWE value below 2.55 m/s for BI-RADS 4a lesions could be used to downstage these lesions to follow-up, and therefore reduce the number of unnecessary biopsies by 24.24 %. However, this would come at the expense of some additionally missed cancers compared to B-mode breast ultrasound (rate of undetected malignancies 1.98 %, 11 of 556, versus 1.39 %, 6 of 431) which would, however, still be in line with the ACR BI-RADS 3 definition (< 2 % of undetected malignancies).

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A novel two-dimensional quantitative shear wave elastography to make differential diagnosis of breast lesions: Comprehensive evaluation and influencing factors

Abstract: The lesion margin and vascularity could affect the measurement of SWS as well as the experience of examiner. However, VTIQ is still a reliable method that provides valuable information in the differential diagnosis of breast lesions, and may reduce unnecessary biopsies.

Cited by 13 publications

References 26 publications

Value of shear wave arrival time contour display in shear wave elastography for breast masses diagnosis

Value of shear wave arrival time contour display in shear wave elastography for breast masses diagnosis

New diagnostic tools for breast cancer

The Potential of Shear Wave Elastography to Reduce Unnecessary Biopsies in Breast Cancer Diagnosis: An International, Diagnostic, Multicenter Trial

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