2020
DOI: 10.3390/toxins12100634
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A Novel Uremic Score Reflecting Accumulation of Specific Uremic Toxins More Precisely Predicts One-Year Mortality after Hemodialysis Commencement: A Retrospective Cohort Study

Abstract: Uremic toxins (UTs) generally accumulate in patients developing end-stage renal disease (ESRD). Although some kinds of UTs cause early death after starting hemodialysis (HD), it remains unknown whether the degree of excessive accumulation of various UTs is associated with worsening of prognosis. We retrospectively conducted this cohort study consisting of adult patients developing ESRD who initiated HD at the National Center for Global Health and Medicine from 2010 to 2019. We created a new uremic score, which… Show more

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Cited by 2 publications
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“…In ESRD patients undergoing hemodialysis with RLS, the occurrence of RLS is closely related to reduced /absent RKF ( 41 ), which is consistent with our study. The deterioration of RKF may aggravate anemia, inflammation, and malnutrition ( 42 ). Besides that, RKF could also affect the clearance of small and medium molecules ( 43 ), which may be a vital mechanism of RLS.…”
Section: Discussionmentioning
confidence: 99%
“…In ESRD patients undergoing hemodialysis with RLS, the occurrence of RLS is closely related to reduced /absent RKF ( 41 ), which is consistent with our study. The deterioration of RKF may aggravate anemia, inflammation, and malnutrition ( 42 ). Besides that, RKF could also affect the clearance of small and medium molecules ( 43 ), which may be a vital mechanism of RLS.…”
Section: Discussionmentioning
confidence: 99%