A novel wireless implant for central venous pressure measurement: First animal experience

Manavi, Tejaswini; Vázquez, Patricia; O’Grady, Helen; Martina, Jerson R.; Rose, Michael; Nielsen, Douglas; FitzPatrick, D.; Forouzan, Omid; Nagy, Michael W.; Sharif, Faisal; Zafar, Haroon

doi:10.1016/j.cvdhj.2020.10.004

Cited by 2 publications

(4 citation statements)

References 28 publications

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“…Administration of additional saline to induce fluid overload indicated an increase in pressure in both SVC and IVC (3.7 and 2.7 mm Hg, respectively). In addition, a Bland Altman analysis illustrated a good correlation between sensor measurements and the Millar reference (Millar Instruments, Inc., Houston, TX, USA) [76]. According to recent literature studies focusing on hemodynamic HF monitoring, this is the only study that explored simultaneous measurements of pressures in three locations (IVC, SVC, and PA) in the same animal.…”

Section: Central Venous Pressure (Cvp) Monitoringmentioning

confidence: 99%

“…[ 53 , 75 ]. Future HF monitoring systems rely on venous sensing to track systemic congestion and detect changes in intravascular volume through real-time monitoring of CVP and IVC area [ 72 , 73 , 76 , 77 ].…”

Section: Sensor-based Hf Monitoringmentioning

confidence: 99%

Section: Sensor-based Hf Monitoringmentioning

confidence: 99%

“… ( a ) IVC sensor for wireless CVP measurement; ( b ) Representation of IVC sensor deployment in a silicone bench-model of IVC; ( c ) Representation of IVC sensor implantation in a sheep model [ 76 , 78 ], Creative Commons CC BY License. …”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

An Era of Digital Healthcare—A Comprehensive Review of Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management

Manavi,

Zafar,

Sharif

2024

Sensors

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Heart failure (HF) is a multi-faceted, complex clinical syndrome characterized by significant morbidity, high mortality rate, reduced quality of life, and rapidly increasing healthcare costs. A larger proportion of these costs comprise both ambulatory and emergency department visits, as well as hospital admissions. Despite the methods used by telehealth (TH) to improve self-care and quality of life, patient outcomes remain poor. HF management is associated with numerous challenges, such as conflicting evidence from clinical trials, heterogeneity of TH devices, variability in patient inclusion and exclusion criteria, and discrepancies between healthcare systems. A growing body of evidence suggests there is an unmet need for increased individualization of in-hospital management, continuous remote monitoring of patients pre and post-hospital admission, and continuation of treatment post-discharge in order to reduce re-hospitalizations and improve long-term outcomes. This review summarizes the current state-of-the-art for HF and associated novel technologies and advancements in the most frequently used types of TH (implantable sensors), categorizing devices in their preclinical and clinical stage, bench-to-bedside implementation challenges, and future perspectives on remote HF management to improve long-term outcomes of HF patients. The Review also highlights recent advancements in non-invasive remote monitoring technologies demonstrated by a few pilot observational prospective cohort studies.

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Section: Central Venous Pressure (Cvp) Monitoringmentioning

confidence: 99%

Section: Sensor-based Hf Monitoringmentioning

confidence: 99%

Section: Sensor-based Hf Monitoringmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

An Era of Digital Healthcare—A Comprehensive Review of Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management

Manavi,

Zafar,

Sharif

2024

Sensors

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Dynamic Narrowing of the Diaphragmatic Vena Cava in Ovis aries

Schwartzman,

Turner,

Spiess

et al. 2024

Anat Histol Embryol

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Dorset sheep (Ovis aries) are common models in translational cardiovascular research due to physiologic and anatomic similarities to humans. While employing ovine subjects to study single‐ventricle physiology, we repeatedly observed position‐based changes in central venous pressure (CVP) which could not be explained by hydrostatic (gravitational) effects. Inferior vena cava (IVC) narrowing or compression has been demonstrated in numerous species, and we hypothesised that this phenomenon might explain our observations in O. aries. This study aimed to characterise position‐dependent morphology of the IVC in O. aries using catheter‐based hemodynamic and dimensional measurements, three‐dimensional MRI reconstruction and histological analysis. Baseline measurements revealed a significant reduction in IVC dimensions at the level of the diaphragm (dVC) compared to the abdominal vena cava (aVC) and thoracic vena cava (tVC). We also observed a transdiaphragmatic pressure gradient along the IVC, with higher pressures in the aVC compared to the tVC. We found that variation of position and fluid status altered IVC haemodynamics. Histological data showed variable muscularity along the length of the IVC, with greater smooth muscle content in the aVC than the tVC. These findings will improve understanding of baseline ovine physiology, help refine experimental protocols and facilitate the translation of findings to the clinic.

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A novel wireless implant for central venous pressure measurement: First animal experience

Cited by 2 publications

References 28 publications

An Era of Digital Healthcare—A Comprehensive Review of Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management

An Era of Digital Healthcare—A Comprehensive Review of Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management

Dynamic Narrowing of the Diaphragmatic Vena Cava in Ovis aries

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