2023
DOI: 10.1002/cbic.202200669
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A Nucleophilic Activity‐Based Probe Enables Profiling of PLP‐Dependent Enzymes

Abstract: PLP-dependent enzymes represent an important class of highly "druggable" enzymes that perform a wide array of critical reactions to support all organisms. Inhibition of individual members of this family of enzymes has been validated as a therapeutic target for pathologies ranging from infection with Mycobacterium tuberculosis to epilepsy. Given the broad nature of the activities within this family of enzymes, we envisioned a universally acting probe to characterize existing and putative members of the family t… Show more

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