A Numerical Approach for Dielectrophoretic Characterization and Separation of Human Hematopoietic Cells

Erdem, Nurdan; Yıldızhan, Yağmur; Elitaş, Meltem

doi:10.17577/ijertv6is040730

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Due to its ease of use and gentle handling, it also allows the separation and trapping system to operate in a continuous mode [10]. While DEP is not only label-free, accurate, fast, and low-cost [11,12] also it can separate bioparticles on the basis of their sizes regardless of whether the particles are alive or dead. [13,14].…”

Section: Introductionmentioning

confidence: 99%

Integration Of Acoustophoresis and Dielectrophoresis on A Single Chip Platform: A Numerical Study

Anjam Waheed,

Muhammad Ramdzan Buyong,

M. F Mohd Razip Wee

2024

IJNeaM

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Passive or active manipulation forces would be needed for the microfluidic system for chemical and biological analysis in order to regulate, trap, separate, sort, and discriminate between particles and cells. The primary goals of passive manipulation are consistency and repeatability to attain high levels of control with exact trajectories. In the meantime, by introducing external forces like hydrodynamic, dielectrophoretic, magnetophoretic, acoustophoretic, and optical tweezing, the active manipulations allow to control particle displacement in a highly predictable and consistent fashion. These methods are much more promising for the development of a small and compact biomedical diagnostic rapid test. Since most biological particles are suspended in different biological fluids like blood and urine, dielectrophoresis (DEP) and acoustophoresis (ACP) have been demonstrated to be promising among these external forces because of their ability to apply forces on the particles in a liquid environment. Additionally, both techniques are fast, inexpensive to fabricate, label-free, and incredibly selective. In this study, we introduce a novel method that combines these two forces into a single chip, improving the separation process for ACP and DEP based on the intrinsic dielectric and acoustic properties of the particles, respectively. It is anticipated that this research would shed light on why particular manipulative factors predominate more or less in particular situations.

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Section: Introductionmentioning

confidence: 99%

Integration Of Acoustophoresis and Dielectrophoresis on A Single Chip Platform: A Numerical Study

Anjam Waheed,

Muhammad Ramdzan Buyong,

M. F Mohd Razip Wee

2024

IJNeaM

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A Microfluidic Channel for Separation of Circulating Tumor Cells from Blood Cells Using Dielectrophoresis and Its Performance Analysis Using Adaptive Neuro-Fuzzy Inference System

Ullah

Khorshed

Amin

2022

2022 4th International Conference on Biomedical Engineering (IBIOMED)

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Signal-Based Methods in Dielectrophoresis for Cell and Particle Separation

et al. 2022

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Separation and detection of cells and particles in a suspension are essential for various applications, including biomedical investigations and clinical diagnostics. Microfluidics realizes the miniaturization of analytical devices by controlling the motion of a small volume of fluids in microchannels and microchambers. Accordingly, microfluidic devices have been widely used in particle/cell manipulation processes. Different microfluidic methods for particle separation include dielectrophoretic, magnetic, optical, acoustic, hydrodynamic, and chemical techniques. Dielectrophoresis (DEP) is a method for manipulating polarizable particles’ trajectories in non-uniform electric fields using unique dielectric characteristics. It provides several advantages for dealing with neutral bioparticles owing to its sensitivity, selectivity, and noninvasive nature. This review provides a detailed study on the signal-based DEP methods that use the applied signal parameters, including frequency, amplitude, phase, and shape for cell/particle separation and manipulation. Rather than employing complex channels or time-consuming fabrication procedures, these methods realize sorting and detecting the cells/particles by modifying the signal parameters while using a relatively simple device. In addition, these methods can significantly impact clinical diagnostics by making low-cost and rapid separation possible. We conclude the review by discussing the technical and biological challenges of DEP techniques and providing future perspectives in this field.

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A Numerical Approach for Dielectrophoretic Characterization and Separation of Human Hematopoietic Cells

Cited by 3 publications

References 36 publications

Integration Of Acoustophoresis and Dielectrophoresis on A Single Chip Platform: A Numerical Study

Integration Of Acoustophoresis and Dielectrophoresis on A Single Chip Platform: A Numerical Study

A Microfluidic Channel for Separation of Circulating Tumor Cells from Blood Cells Using Dielectrophoresis and Its Performance Analysis Using Adaptive Neuro-Fuzzy Inference System

Signal-Based Methods in Dielectrophoresis for Cell and Particle Separation

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