A numerical investigation into the magnetic nanoparticles hyperthermia cancer treatment injection strategies

Dahaghin, Ali; Emadiyanrazavi, Seyedhamidreza; Salimibani, Milad; Bahreinizad, Hossein; Haghpanahi, Mohammad; Eivazzadeh‐Keihan, Reza; Maleki, Ali

doi:10.1016/j.bbe.2021.04.002

Cited by 15 publications

(6 citation statements)

References 51 publications

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“…In this method, after injecting magnetic nanoparticles to the patient and applying AMF, magnetic nanoparticles vibration induced Brownian and N´eel relaxation. By vibration of metal nanoparticles, the temperature of cancer cells raises (42-46 °C) and tumors are destroy [27][28][29]…”

Section: Introductionmentioning

confidence: 99%

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Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

et al. 2023

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Section: Introductionmentioning

confidence: 99%

“…During the vibration of metal nanoparticles, the temperature of cancer cells raises (42-46 °C) and tumors are destroyed. [27][28][29]…”

Section: Introductionmentioning

confidence: 99%

Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

et al. 2023

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“…On this subject, selecting appropriate NPs due to their features, composition, and related function have been widely reported 34 – 37 . The injection strategy is another effective parameter in MNPs hyperthermia process 35 . MNPs reach the tumor tissue either by injection or intravenously.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a magnetic alginate-silk fibroin hydrogel, containing halloysite nanotubes as a novel nanocomposite for biological and hyperthermia applications

Eivazzadeh‐Keihan

Sadat

Aliabadi

et al. 2022

Sci Rep

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In this study, the main focus was on designing and synthesizing a novel magnetic nanobiocomposite and its application in hyperthermia cancer treatment. Regarding this aim, sodium alginate (SA) hydrogel with CaCl2 cross-linker formed and modified by silk fibroin (SF) natural polymer and halloysite nanotubes (HNTs), followed by in situ Fe3O4 magnetic nanoparticles preparation. No important differences were detected in red blood cells (RBCs) hemolysis, confirming the high blood compatibility of the treated erythrocytes with this nanobiocomposite. Moreover, the synthesized SA hydrogel/SF/HNTs/Fe3O4 nanobiocomposite does not demonstrate toxicity toward HEK293T normal cell line after 48 and 72 h. The anticancer property of SA hydrogel/SF/HNTs/Fe3O4 nanobiocomposites against breast cancer cell lines was corroborated. The magnetic saturation of the mentioned magnetic nanobiocomposite was 15.96 emu g−1. The specific absorption rate (SAR) was measured to be 22.3 W g−1 by applying an alternating magnetic field (AMF). This novel nanobiocomposite could perform efficiently in the magnetic fluid hyperthermia process, according to the obtained results.

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“…Metal NPs play an important role in a variety of biological applications, including anti-microbial and anti-bacterial materials, biosensing, drug delivery, bio-imaging, and etc. 4 , 35 – 38 . There are various methods for the synthesis of metal oxide NPs, which can be referred to mechanical milling, laser ablation, ion sputtering, physical vapor deposition, chemical vapor deposition, sol–gel, chemical reduction, hydrothermal, solvothermal, spray pyrolysis, laser pyrolysis, and flame pyrolysis 39 .…”

Section: Introductionmentioning

confidence: 99%

A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles

Eivazzadeh‐Keihan

Zare-Bakheir

Aliabadi

et al. 2022

Sci Rep

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In this study, a novel nanobiocomposite was synthesized using graphene oxide, lignin, silk fibroin and ZnO and used in biological fields. To synthesize this structure, after preparing graphene oxide by the Hummer method, lignin, silk fibroin, and ZnO nanoparticles (NPs) were added to it, respectively. Also, ZnO NPs with a particle size of about 18 nm to 33 nm was synthesized via Camellia sinensis extract by green methodology. The synthesized structure was examined as anti-biofilm agent and it was observed that the Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite has a significant ability to prevent the formation of P. aeruginosa biofilm. In addition, due to the importance of the possibility of using this structure in biological environments, its toxicity and blood compatibility were also evaluated. According to the obtained results from MTT assay, the viability percentages of Hu02 cells treated with Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite after 24, 48, and 72 h of incubation were 89.96%, 89.32%, and 91.28%. On the other hand, the hemolysis percentage of the synthesized structure after 24 h and 72 h of extraction was 9.5% and 11.76% respectively. As a result, the synthesized structure has a hemolysis percentage below 12% and its toxicity effect on Hu02 cells is below 9%.

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A numerical investigation into the magnetic nanoparticles hyperthermia cancer treatment injection strategies

Cited by 15 publications

References 51 publications

Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

Fabrication of a magnetic alginate-silk fibroin hydrogel, containing halloysite nanotubes as a novel nanocomposite for biological and hyperthermia applications

A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles

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