A nutrigenomic approach to detect nutritional stress from gene expression in blood samples drawn from Steller sea lions

Spitz, Jérôme; Becquet, Vanessa; Rosen, David A. S.; Trites, Andrew W.

doi:10.1016/j.cbpa.2015.02.006

Cited by 18 publications

(12 citation statements)

References 73 publications

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“…Both pregnancy and lactating states are energetically the costliest (Scantlebury et al, 2000;Kastelein et al, 2002) and therefore requires increased food intake (East et al, 2015). In the TZO population, the significantly high expression of THRα during pregnancy could reflect reduced feeding resources (Martinez et al, 2013;Spitz et al, 2015), although lactation is even more energy demanding than the pregnant state (East et al, 2015). However, we did not observe a significantly high expression of THRα in lactating animals living in the TZO.…”

Section: Discussioncontrasting

confidence: 60%

“…Thyroid hormones (T 3 and T 4 ) and thyroid hormone receptors (THRα and THRβ) have an essential role in the regulation of cetacean metabolism. In cetaceans, diet restriction reduces circulating T 3 levels but upregulates the expression of both THRα and THRβ levels (Martinez et al, 2013;Spitz et al, 2015). This high level of empty THR (without T 3 ) further activates the generally negative regulation of the gene coding for Thyroid Stimulating Hormone (TSH) which reduces T 3 levels (Oppenheimer and Samuels, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 15 genes were investigated in both porpoise populations ( Table 2). Four genes (HSP14, SOD1, TXN, and FTL) were implicated in a generalized stress response (Cantú-Medellín et al, 2011;Silva-Adaya et al, 2014;Theriot et al, 2016;Garbuz, 2017), and two genes (ACAT2 and THRA) were implicated in metabolic stress (Spitz et al, 2015). The remaining nine genes were implicated as part of an immune response, in which five (IL12p40, IFNγ, TNFα, IL1α, and IL1ra) were proinflammatory cytokines (von der Thusen et al, 2003;Collison and Vignali, 2008;Turner et al, 2014) and two (COX2 and CRPL) were proinflammatory mediators (Lagrand et al, 2002;Gandhi et al, 2017).…”

Section: Candidate Genes Primer Design and Qpcrmentioning

confidence: 99%

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Immune Responses of the Critically Endangered Yangtze Finless Porpoises (Neophocaena asiaeorientalis ssp. asiaeorientalis) to Escalating Anthropogenic Stressors in the Wild and Seminatural Environments

Nabi

McLaughlin

et al. 2020

Front. Physiol.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Candidate Genes Primer Design and Qpcrmentioning

confidence: 99%

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Immune Responses of the Critically Endangered Yangtze Finless Porpoises (Neophocaena asiaeorientalis ssp. asiaeorientalis) to Escalating Anthropogenic Stressors in the Wild and Seminatural Environments

Nabi

McLaughlin

et al. 2020

Front. Physiol.

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“…At the level of the individual, nutritional stress would be expected to affect steroid hormone levels, but we have no data to explore this possibility and it seems very unlikely that this could explain any differences between closely neighbouring colonies. One way to tackle this question in the future might be through ‘nutrigenomics’, the use of gene expression data from peripheral blood to assess an animal’s nutritional status [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Offspring Hormones Reflect the Maternal Prenatal Social Environment: Potential for Foetal Programming?

et al. 2016

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Females of many species adaptively program their offspring to predictable environmental conditions, a process that is often mediated by hormones. Laboratory studies have shown, for instance, that social density affects levels of maternal cortisol and testosterone, leading to fitness-relevant changes in offspring physiology and behaviour. However, the effects of social density remain poorly understood in natural populations due to the difficulty of disentangling confounding influences such as climatic variation and food availability. Colonially breeding marine mammals offer a unique opportunity to study maternal effects in response to variable colony densities under similar ecological conditions. We therefore quantified maternal and offspring hormone levels in 84 Antarctic fur seals (Arctocephalus gazella) from two closely neighbouring colonies of contrasting density. Hair samples were used as they integrate hormone levels over several weeks or months and therefore represent in utero conditions during foetal development. We found significantly higher levels of cortisol and testosterone (both P < 0.001) in mothers from the high density colony, reflecting a more stressful and competitive environment. In addition, offspring testosterone showed a significant positive correlation with maternal cortisol (P < 0.05). Although further work is needed to elucidate the potential consequences for offspring fitness, these findings raise the intriguing possibility that adaptive foetal programming might occur in fur seals in response to the maternal social environment. They also lend support to the idea that hormonally mediated maternal effects may depend more strongly on the maternal regulation of androgen rather than cortisol levels.

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“…Furthermore, thyroid hormones stimulate insulin-dependent cellular uptake of glucose and improve blood flow to different body organs (5). Gene coding for thyroid hormones and their receptors are probably among the most suitable set of genes to build a molecular biomarker of nutritional stress (6). It is worth mentioning that circulating thyroid hormones levels are used as biomarkers for the metabolic and nutritional efficiency of individual animals (7,8), where the levels of hormones were reported to be genetically determined (9).…”

Section: Introductionmentioning

confidence: 99%

Correlation of blood triiodothyronine (T3) level with some production traits in male goat kids

Abdoun¹,

Samara²,

Okab³

et al. 2018

Turk J Vet Anim Sci

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Thyroid hormones are known for their stimulation of feed efficiency and growth performance in different farm animals. More interestingly, the level of thyroid hormones is influenced by selection for growth in some animal species. Therefore, it was the aim of the current study to investigate whether a correlation exists between the blood triiodothyronine (T 3 ) level and some production traits (daily feed intake, average daily gain, and feed conversion ratio). To test this hypothesis, six male goat kids (21.9 ± 2.4 kg; 5 months old) belonging to Aardi, Damascus, and their cross breed (two kids from each genotype) were used in the current study. The obtained results revealed a positive linear correlation of plasma T 3 level with both average daily feed intake and average daily gain with correlation coefficients of 99% and 97%, respectively (P ≤ 0.001). On the other hand, feed conversion ratio was negatively correlated to the plasma T 3 level with a correlation coefficient of 81% (P = 0.05). The obtained results indicate the possible use of blood T 3 level for the prediction of feed intake, daily body weight gain, and feed conversion ratio in addition to the possible use of blood T 3 level as a criterion of breeding selection for growth performance in the future.

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A nutrigenomic approach to detect nutritional stress from gene expression in blood samples drawn from Steller sea lions

Cited by 18 publications

References 73 publications

Immune Responses of the Critically Endangered Yangtze Finless Porpoises (Neophocaena asiaeorientalis ssp. asiaeorientalis) to Escalating Anthropogenic Stressors in the Wild and Seminatural Environments

Immune Responses of the Critically Endangered Yangtze Finless Porpoises (Neophocaena asiaeorientalis ssp. asiaeorientalis) to Escalating Anthropogenic Stressors in the Wild and Seminatural Environments

Offspring Hormones Reflect the Maternal Prenatal Social Environment: Potential for Foetal Programming?

Correlation of blood triiodothyronine (T3) level with some production traits in male goat kids

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