A one-pot, efficient and facile synthesis of 4β-arylaminopodophyllotoxins: synthesis of NPF and GL-331 as DNA topoisomerase II inhibitors

4β-[(4-Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: Design, synthesis and biological evaluation

“…Docking results of these ligands are given in Table 1. Compounds 12,13,20,21,22 and 29 showed good interaction with TP-II and these results were matching with wet lab findings. Compound 20 was found to have a score of À4.08 with 3 strong Hbonds with Arg98 and 2 Hbonds with Ser149 with strengths of 2.14 Å and 1.83 Å.…”

“…Compounds 9 and 10 were synthesised according to literature procedures [21,22]. Compound 9 was obtained by the reaction of podophyllotoxin with CH 3 SO 3 H and NaI in acetonitrile followed by hydrolysis with H 2 O/Me 2 CO/BaCO 3 and reaction with NaN 3 in TFA.…”

“…However, a lesser activity was observed against A-549 cancer cell line. Compounds 12,13,20,21,22 Scheme-1. Click-chemistry strategy for the synthesis of 4b-[(4-alkyl)-1,2,3-triazol-1-yl] podophyllotoxin derivatives.…”

Synthesis and Bioevaluation Study of Benzofuran Linked Tetralones as Antimitotic Agent

“…etopophos which are more potent antitumor agents than 4'-o-demethylepipodophyllotoxin. These have been approved for many years for clinical use in the treatment of various types of cancers (breast, testicular, small cell lung cancer, lymphomas, Kaposi's sarcoma, nonlymphocytic leukemia) [10][11][12][13] .…”

Synthesis of succinic acid 12α-deoxoartemisinyl ester 4′-O-demethyl-4β-(4″-nitroanilino)-4-desoxypodophyllotoxin

“…Elemental analyses corresponded with those calculated. GL331 was prepared by the literature method [14].…”