A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation

Abstract

A series of substituted dihydropyrimidin-2(1H)-thione derivatives (1–8) have been synthesized and docked against enzymes human topoisomerase II alpha (4FM9) and Helicobacter pylori urease (1E9Y) for binding mode validation.

Bioactive Heteroleptic Bismuth(V) Complexes: Synthesis, Structural Analysis and Binding Pattern Validation

“…Methyl proton signals for p ‐tolyl groups for ( 4 – 7) appear around 3.40 ppm. The 13 C NMR data for the compounds demonstrate that the resonances correspond very well with the presence of magnetically non‐equivalent carbons and the values have been assigned by comparing experimental chemical shift values with those calculated from the incremental method . The carboxylic carbons appear in most down field region in range 174.7–169.6 ppm.…”

“…Moreover, the carboxylate functionality bearing hydroxyl and methoxy groups facilitate the absorption of the respective compounds in the biological systems through the formation of hydrogen bonds. The moderate activity against L. tropica promastigotes was observed for ( 1 , 5 ) in spite of that significant reduction in population of L. tropica infected cells occur …”

Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine

“…30 Cetirizine is usually restrained from crossing the blood-brain barrier and, consequently, has diminished impact on the central nervous system in contrast to first-generation drugs, for example, it has less possibility to induce sleepiness or to interfere with memory creation. 31 Keeping in mind the above aspects and in continuation of previous research work, [32][33][34][35][36][37] herein the synthesis and biological activities of organotin(IV) complexes of flumequine and cetirizine are reported to evaluate further their biological significance in comparison to their previous function as patent drugs.…”

New Substituted 1‐Aryl‐4,4,6‐Trimethyl‐3,4‐Dihydropyrimidine‐2‐(1H)Thiones; A Metal‐Free and Solvent‐Free Synthesis, Characterization, and Lymphoid Tyrosine Phosphatase Inhibition Studies

“…During the optimization of the reaction conditions, it was noted that the reactions proceed smoothly in the presence of a Brønsted acid catalyst. On the other hand, during the preparation of this manuscript, another group using our designed procedure reported the synthesis of these compounds using expensive, toxic, and eco‐unfriendly transition‐metal catalysts with no citation of our work . This prompted us to report our original work involving a one‐pot, two component, essentially metal‐catalyst‐ or solvent‐free synthesis of a series of new pyrimidine2‐thiones.…”

“…On the other hand, during the preparation of this manuscript, another group using our designed procedure reported the synthesis of these compounds using expensive, toxic, and eco-unfriendly transition-metal catalysts with no citation of our work. 15 This prompted us to report our original work involving a one-pot, two component, essentially metal-catalyst-or solvent-free synthesis of a series of new pyrimidine2-thiones. In fact, there is no need in any way to involve any transition-metal catalyst, and the reaction proceeds smoothly with good yields, with a simple purification by recrystallization only.…”