A One-Step Approach to the Highly Efficient Preparation of Core-Stabilized Polymeric Micelles with a Mixed Shell Formed by Two Incompatible Polymers

Surface Phase Separation and Morphology of Stimuli Responsive Complex Micelles

“…A similar method had been described by Chen and coworkers. [8] Here, complex micelles with a common P4VP core and a mixed PNIPAM/PEG shell were formed instead of a simple mixture of PNIPAM-b-P4VP micelles and PEG-b-P4VP micelles. It was confirmed by the stability of the micellar solutions during heating.…”

“…Chen and coworkers [8] reported the preparation of core-stabilized polymeric micelles with a mixed PEO/PS shell and the ''fine phase separation'' between PEO and PS in selective nonsolvents. However, this process was complex and actually not reversible because dialysis was needed to replace DMF with water and/or dioxane.…”

Formation of Complex Micelles with Double‐Responsive Channels from Self‐Assembly of Two Diblock Copolymers

“…[11][12][13][14][15] For example, Jiang and co-workers reported core-stabilized polymeric micelles with a mixed shell made from two incompatible copolymers. [13] Liu and co-workers prepared water-soluble porous nanospheres from block copolymer micelles and nano-or microspheres bearing small hemispherical bumps with surface-segregated chains. [14,15] If the multifunctionality of channels is considered, more advantages would be offered if we combined the properties of polymeric micelles with tunable channels.…”

Fabrication of Complex Micelles with Tunable Shell for Application in Controlled Drug Release

“…[14][15][16][17][18][19][20][21] CSC micelles are usually prepared from either ABC triblock copolymer or two diblock copolymers AB and BC or AB and CD. Since the synthesis of well-defined triblock copolymer is very difficult, the cooperative self-assembly of two different diblock copolymers in their common selective solvents is more favorable to prepare desirable micelles for application in controlled drug release.…”

“…Additionally, the stimuli responsiveness of block copolymer offers extra means to alter the structure and properties, as well as application in specific areas. [20,21] Our group [16] investigated the formation of complex micelles, which were prepared from poly(tert-butyl acrylate)-block-poly-(N-isopropylacryamide) (PtBA-b-PNIPAM) and poly (tertbutyl acrylate)-block-poly(4-vinylpyridine) (PtBA-b-P4VP) diblock copolymers. The structures of complex micelles, with a dense PtBA core and a mixed PNIPAM/P4VP shell, could be changed variably, and the solubility of P4VP and PNIPAM is sensitive to pH and temperature, leading to microphase separation in the micelle coronas and the formation of double-responsive channels.…”