A one-step ester to hydrocarbon reduction

A novel method for the synthesis of methylthiophenes from ketones containing an active methylene group

“…For example, pyrrole-3-carboxylic acid esters can be reduced to the corresponding 3-methylpyrroles by LiAlH 4 . 8,9 Besides that, we have found three examples [10][11][12] of one-pot synthesis of methyl derivatives from methyl carboxylates. The first example 10 concerned the reduction of methyl anthranilate by LiAlH 4 to methylaniline in 96 % yield, but the process takes 20 days at room temperature.…”

“…The first example 10 concerned the reduction of methyl anthranilate by LiAlH 4 to methylaniline in 96 % yield, but the process takes 20 days at room temperature. The second one 11 deals with the reduction of cinnamic acid esters by a mixture of LiAlH 4 and AlCl 3 . In this reaction, a mixture of the target compound and the product of allylic rearrangement was obtained in the ratio 2:1.…”