A paper/polymer hybrid CD-like microfluidic SpinChip integrated with DNA-functionalized graphene oxide nanosensors for multiplex qLAMP detection

Dou, Maowei; Sanjay, Sharma T.; Domı́nguez, Delfina C.; Zhan, Sihui; Li, Xiujun

doi:10.1039/c7cc03246c

Cited by 70 publications

(54 citation statements)

References 31 publications

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“…Such specific treatment decreases the chance of antibiotic-resistant strains of bacteria arising. Automated nucleic acid extraction and miniaturized polymerase chain reaction (PCR) systems for point-of-care testing have already been commercialized 4 – 7 , and isothermal nucleic acid amplification methods such as loop-mediated isothermal amplification, rolling circle amplification, and nicking enzyme amplification reaction have been developed 8 – 10 . Thus, it is expected that a variety of on-site genetic diagnoses will be possible.…”

Section: Introductionmentioning

confidence: 99%

Closed-type pre-treatment device for point-of-care testing of sputum

Park

Woo

Min

et al. 2018

Sci Rep

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The procedures and protocols for the pre-treatment of sputum specimens, mainly used for the diagnosis of pneumonia, are complex, labor intensive, and require skilled specialists working in a biosafety containment laboratory because of sample infectivity. In this study, we developed the first portable, low-power pre-treatment device that carries out all sputum pre-treatment procedures (liquefaction, homogenization, dissolution, and inactivation) in an enclosed space. Designed to simultaneously employ chemical and mechanical dissolution in the enclosed chamber, this device eliminates the risk of transmission and improves the effectiveness of sputum dissolution and pathogen detection. This device is expected to allow for the pre-treatment of infectious sputum specimens outside of a biosafety containment laboratory. Used in conjunction with automated genome extraction and detection systems, this device should make the on-site diagnosis using infectious sputum specimens possible.

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Section: Introductionmentioning

confidence: 99%

Closed-type pre-treatment device for point-of-care testing of sputum

Park

Woo

Min

et al. 2018

Sci Rep

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“…The catalytic reduction reaction from 4-NP to 4-AP follows rst-order kinetics because of the excessive amount of NaBH 4 . The kinetics was calculated using eqn (2).…”

Section: Catalytic Reduction Of 4-npmentioning

confidence: 99%

“…Nanomaterials have attracted increased attention in multiple disciplines due to their unique size and shape effects. [1][2][3][4] As an important member of nanomaterials, noble metal nanocatalysts (Au nanoclusters, Pd nanoparticles, Pt nanoparticles, etc.) have widespread applications in many elds, such as environmental catalysis, [5][6][7] photothermal therapy, [8][9][10] carbon-carbon coupling reactions, [11][12][13] etc.…”

Section: Introductionmentioning

confidence: 99%

Smart paper transformer: new insight for enhanced catalytic efficiency and reusability of noble metal nanocatalysts

et al. 2020

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“…A power-free microfluidic chip was developed by Li et al [42] for fluorescent DNA detection employing a DNA intercalator and GO. For multiplex quantitative LAMP detection for the amplification of DNA Duo et al [43] fabricated a paper/poly(methyl methacrylate) (PMMA) hybrid CD-like micro-fluidic SpinChip integrated with DNA probe-functionalized GO nanosensor which can deal with the problems faced by conventional mLAMP in identifying multiple targets. A highly flexible microfluidic tactile sensor based on GO nanosuspension was reported by Kenry et al [44].…”

Section: Biological Analysismentioning

confidence: 99%

Graphene and its derivatives for Analytical Lab on Chip platforms

Sengupta

Hussain

2019

TrAC Trends in Analytical Chemistry

100

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a b s t r a c tSince last decade, graphene has materialized itself as one of the phenomenal materials to modern researchers because of its remarkable thermal, optical, electronic, and mechanical properties. Graphene holds enormous potentials for lab on chip (LOC) devices and can provide diverse fabrication routes and structural features due to their special electronic and electrochemical properties. A LOC device can manipulate fluids using microchannels and chamber structures, to accomplish fast, highly sensitive and inexpensive analysis with high yield. Hence, the graphene based LOC devices can constitute a wellcontrolled microenvironment for both advanced chemical/biological evaluation and low-cost point-ofcare analysis etc. This review critically debates the graphene as a prime candidate for microfluidic devices and their future applicability towards various practical applications. Finally, the opportunities and challenges for the future of graphene with respect to their commercial challenges and sustainability perspectives are discussed.

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A paper/polymer hybrid CD-like microfluidic SpinChip integrated with DNA-functionalized graphene oxide nanosensors for multiplex qLAMP detection

Cited by 70 publications

References 31 publications

Closed-type pre-treatment device for point-of-care testing of sputum

Closed-type pre-treatment device for point-of-care testing of sputum

Smart paper transformer: new insight for enhanced catalytic efficiency and reusability of noble metal nanocatalysts

Graphene and its derivatives for Analytical Lab on Chip platforms

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