A Paradoxical Response to Methylphenidate in an Experimental Model of Minimal Brain Dysfunction (Mbd) in Developing Rat Pups

Abstract

Previous data in bone organ culture have demonstrated a mobile compartment of Pb regulated like bone mineral. To test for its existence in vivo,after 7mglkg of Pb plus 25vCi '03pb were given IV, TPTX rats were placed in metabolism cages; and 4 days later, EDTA or PTH was infused via a catheterized tail vein for 6 hours. Measurements were made of stable Pb and 2 0 3~b from aliquots of total organs, urinary Pblcreatinine (Pb-U) , and blood Pb (Pb-B) , pg/dl. 3 days later the rats were sacrificed and the cpm of 2 0 3~b from bone (B),liver (L),and kidney (K) were expressed as the X change vs saline-infused controls. The results (*p < .01;**