A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-racial cohort
Faye Orcales,
Sugandh Kumar,
Audrey Bui
et al.
Abstract:Psoriasis is a chronic, immune-mediated inflammatory skin disease associated with a polygenic mode of inheritance. There are few studies that explore the association of a psoriasis Polygenic Risk Score (PRS) with patient clinical characteristics, and to our knowledge there are no studies examining psoriasis PRS associations across different races. In this study, we used a multi-racial psoriasis cohort to investigate PRS associations with clinical phenotypes including age of onset, psoriatic arthritis, other co… Show more
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