2024
DOI: 10.1126/sciadv.ado9516
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A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion

Enoch Lok Him Yuen,
Yasin Tumtas,
Freddie King
et al.

Abstract: Pathogens have evolved sophisticated mechanisms to manipulate host cell membrane dynamics, a crucial adaptation to survive in hostile environments shaped by innate immune responses. Plant-derived membrane interfaces, engulfing invasive hyphal projections of fungal and oomycete pathogens, are prominent junctures dictating infection outcomes. Understanding how pathogens transform these host-pathogen interfaces to their advantage remains a key biological question. Here, we identified a conserved effector, secrete… Show more

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