2024
DOI: 10.1186/s12987-024-00565-1
|View full text |Cite
|
Sign up to set email alerts
|

A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery

Joanna M. Wasielewska,
Juliana C. S. Chaves,
Mauricio Castro Cabral-da-Silva
et al.

Abstract: Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder with minimally effective treatment options. An important hurdle in ALS drug development is the non-invasive therapeutic access to the motor cortex currently limited by the presence of the blood-brain barrier (BBB). Focused ultrasound and microbubble (FUS + MB ) treatment is an emerging technology that was successfully used in ALS patients to temporarily open the cortical BB… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 113 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?