A patient with ulcerative colitis and central serous chorioretinopathy—A therapeutic dilemma

Geyshis, Bella; Katz, Gabriel; Ben‐Horin, Shomron; Kopylov, Uri

doi:10.1016/j.crohns.2012.04.020

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…Dryness is considered as coincidental for some, and as the first EIM for others [ 30 , 47 ]. Furthermore, the association between CSCR and IBD is mentioned in the literature, but usually in a context of corticosteroid use [ 48 , 49 , 50 ]. So, we have decided to classify CSCR in the diagnoses not related to IBD, because an absence of corticosteroid use in this case.…”

Section: Discussionmentioning

confidence: 99%

Ocular Manifestations in Patients with Inflammatory Bowel Disease in the Biologics Era

Cuny

Guillo

Baumann³

et al. 2022

JCM

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Background: Extra-intestinal manifestations are frequent in inflammatory bowel disease (IBD). Ocular disorders are generally under diagnosed as they are challenging diagnosis. Aims: We assessed the prevalence of ophthalmological manifestations in patients with IBD, and investigated characteristics associated with ocular manifestations. Methods: We performed a retrospective study including patients followed for IBD and had an ophthalmologic visit from January 2013 to July 2020, among 1432 patients followed during this period. Two groups were considered: the first group included patients whose an ocular diagnosis was considered as “related to IBD”, and the second group including patients whose an ocular diagnosis was considered “not related to IBD”. Results: Among 1432 patients with IBD, eighty-seven (6.1%) patients had an ophthalmologic visit. Fifty-three patients (3.7%) were considered to have an ocular extra-intestinal manifestation or an iatrogenic effect of IBD treatment, and 34 diagnoses (2.4%) were considered not related to IBD. Inflammatory surface pathologies were the most frequent (33.2%), including 15 patients with dry eye (17.2%), 9 with blepharitis (10.3%), and 5 with chalazions (meibomian cyst) (5.7%). Uveitis was diagnosed in 13 patients (14.9%), episcleritis in 5 patients (5.7%), and scleritis in 2 patients (2.3%). Characteristics of patients with an ophthalmological diagnosis “related to IBD” versus “not related to IBD” were not statistically different. Conclusion: In our cohort, less than 5% of patients had ophthalmological extra-intestinal manifestation. The most frequent ocular diagnosis were dry eye and uveitis. No disease characteristics of IBD were found to be associated with ocular manifestations.

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Section: Discussionmentioning

confidence: 99%

Ocular Manifestations in Patients with Inflammatory Bowel Disease in the Biologics Era

Cuny

Guillo

Baumann³

et al. 2022

JCM

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“…Many gastrointestinal disease states such as gastroesophageal reflux disease (GERD), Helicobacter pylori infection, and inflammatory bowel disease have been linked with CSC. [ 131 132 ] However, it may very well be the case that this association is indirect, as inflammatory bowel diseases (ulcerative colitis and Crohn's disease) are often treated with corticosteroids. Alternatively, the associated ocular inflammation may provide a milieu conducive to choroidal hemodynamic alteration.…”

Section: Gastrointestinal System and Central Serous Chorioretinopathymentioning

confidence: 99%

“…Alternatively, the associated ocular inflammation may provide a milieu conducive to choroidal hemodynamic alteration. [ 132 ]…”

Section: Gastrointestinal System and Central Serous Chorioretinopathymentioning

confidence: 99%

Central serous chorioretinopathy

Jain¹,

Mohan

Dijk

2022

Taiwan Journal of Ophthalmology

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Central serous chorioretinopathy (CSC) has remained an enigmatic disease since its initial description by Von Graefe. Over the years, multiple risk factors have been recognized: these include psychological stress, behavioral traits, and corticosteroids. The basic pathophysiology of CSC involves choroidal thickening, vascular congestion, altered choroidal blood flow (ChBF), and choroidal hyperpermeability, leading to retinal pigment epithelium decompensation and subsequent neurosensory detachment. Multiple organ systems, mainly the nervous, cardiovascular, endocrinal, and renal systems participate in the control of the vascular tone and the ChBF via hypothalamus–pituitary–adrenal axis and renin–angiotensin–aldosterone system, while others such as the hepatic system regulate the enzymatic degradation of corticosteroids. Many vasoactive and psychotropic drugs also modulate the ocular perfusion. In addition, there are anatomical and genetic predispositions that determine its progression to the chronic or recurrent form, through cellular response and angiogenesis. We herein review the basic pathophysiology and immunogenetics in CSC along with the role of multiple organ systems. With this background, we propose an etiological classification that should provide a framework for customized therapeutic interventions.

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Central Serous Chorioretinopathy in a Patient with Ulcerative Colitis with Pouchitis on Budesonide-EC

Zullow

Fazelat²,

Farraye

2017

Inflammatory Bowel Diseases

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A patient with ulcerative colitis and central serous chorioretinopathy—A therapeutic dilemma

Cited by 5 publications

References 14 publications

Ocular Manifestations in Patients with Inflammatory Bowel Disease in the Biologics Era

Ocular Manifestations in Patients with Inflammatory Bowel Disease in the Biologics Era

Central serous chorioretinopathy

Central Serous Chorioretinopathy in a Patient with Ulcerative Colitis with Pouchitis on Budesonide-EC

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