A Peek Into the Future: Will Serial Multimarker Testing Help Bring a New Era of Precision Medicine in Heart Failure Patients?

Alzate, James A; Rajendran, Pradeep S.; Gaggin, Hanna K.

doi:10.1161/circheartfailure.122.010156

Cited by 1 publication

(1 citation statement)

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“…[64][65][66] Another strategy to demonstrate the clinical value of protein signatures may be when serial multi-marker testing becomes feasible to generate multi-marker scores. 67 Similar to PRS, these scores can be utilized to predict disease incidence, progression, and outcome. They could also inform drug target discovery as well as treatment response prediction, which can be utilized to further personalize treatment strategies.…”

Section: Proteomicsmentioning

confidence: 99%

Using Omics to Identify Novel Therapeutic Targets in Heart Failure

Lteif,

Huang,

Guerra

et al. 2024

Circ: Genomic and Precision Medicine

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Omics refers to the measurement and/or analysis of the totality of molecules or biological processes involved within an organism. Examples of omics data include genomics, transcriptomics, epigenomics, proteomics, metabolomics, and more. In this review, we present the available literature reporting omics data on heart failure that can inform the development of novel treatments or innovative treatment strategies for this disease. This includes polygenic risk scores to improve prediction of genomic data and the potential of multiomics to more efficiently identify potential treatment targets for further study. We also discuss the limitations of omic analyses and the barriers that must be overcome to maximize the utility of these types of studies. Finally, we address the current state of the field and future opportunities for using multiomics to better personalize heart failure treatment strategies. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01960946.

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Section: Proteomicsmentioning

confidence: 99%