A PEG-based hydrogel for effective wound care management

Abstract

It is extremely challenging to achieve strong adhesion in soft tissues while minimizing toxicity, tissue damage, and other side effects caused by wound sealing materials. In this study, flexible synthetic hydrogel sealants were prepared based on polyethylene glycol (PEG) materials. PEG is a synthetic material that is nontoxic and inert and, thus, suitable for use in medical products. We evaluated the in vitro biocompatibility tests of the dressings to assess cytotoxicity and irritation, sensitization, pyrogen toxicity, and systemic toxicity following the International Organization for Standardization 10993 standards and the in vivo effects of the hydrogel samples using Coloskin liquid bandages as control samples for potential in wound closure.

Polyethylene Glycol–Based Nanocerium Improves Healing Responses in Excisional and Incisional Wound Models in Rats

“…Polyethylene glycol is a synthetic material that is nontoxic and inert, thus suitable for use in medical products. 27 Findings of the present study demonstrated that PEG in combination with nanocerium significantly improved the wound healing rate in rats. It could be hypothesized that PEG as a matrix enhanced the beneficial effects of the cerium oxide nanoparticles on wound healing that need expanded studies to support the idea.…”

“…Furthermore, the high surface area, increased Ce 3+ /Ce 4+ ratio, and small size make cerium oxide nanoparticles more catalytically active toward regulating intracellular oxygen, which in turn leads to more robust induction of angiogenesis. 27 Therefore, in the present study, cerium nanoxide solely or in combination with PEG significantly improved the wound healing process.…”

Applications ofhydrogel‐baseddelivery systems in wound care and treatment: Anup‐to‐datereview

“…However, PVP‐chitosan hydrogels loaded with silver nanoparticles brought about a rapid reduction in the wound size and exhibited antibacterial activity against P. aeruginosa and S. aureus 65 . Polyethylene glycol (PEG) is a synthetic hydrophilic polymer used in medical products that are non‐toxic and inert 66 …”

Recent advances of hydrogel‐based biomaterials for intervertebral disc tissue treatment: A literature review

“…Because of its biocompatibility, nonimmunogenicity, degradability, and modifiability, poly(ethylene glycol) (PEG) is widely applied in wound healing and drug delivery (Bodratti & Alexandridis, 2018; S. L. Chen et al., 2018; Tan et al., 2019). Besides, PEG also performs multiple functions in research of IVD regeneration such as a nontoxic hydrogel crosslinker and a potential replacement candidate (Collin et al., 2011; Nicodemus, Skaalure, & Bryant, 2011).…”