A performance test of a new high-surface-quality and high-sensitivity CR-39 plastic nuclear track detector – TechnoTrak

Kodaira, Satoshi; Morishige, Kunimitsu; Kawashima, Hiroki; Kitamura, Hisashi; Kurano, M.; Hasebe, Nobuyuki; Koguchi, Yasuhiro; Shinozaki, Wakako

doi:10.1016/j.nimb.2016.07.002

Cited by 41 publications

(35 citation statements)

References 37 publications

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“…The principle of heavy ion detection has been described elsewhere. 21,24 In brief, a heavy ion passes through the CR-39 detector and causes latent track damage. CR-39 has the ether and two carbonate esters, that are composed of carbonyl (C = O) and C-O-C bonds, in the center.…”

Section: A Cr-39 Plastic Charged Particle Detectorsmentioning

confidence: 99%

Estimations of relative biological effectiveness of secondary fragments in carbon ion irradiation of water using CR‐39 plastic detector and microdosimetric kinetic model

et al. 2019

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Purpose To estimate relative biological effectiveness (RBE) ascribed to secondary fragments in a lateral distribution of carbon ion irradiation. The RBE was estimated with the microdosimetric kinetic (MK) model and measured linear energy transfer (LET) obtained with CR‐39 plastic detectors. Methods A water phantom was irradiated by a 12C pencil beam with energy of 380 MeV/u at the Gunma University Heavy Ion Medical Center (GHMC), and CR‐39 detectors were exposed to secondary fragments. Because CR‐39 was insensitive to low LET, we conducted Monte Carlo simulations with Geant4 to calculate low LET particles. The spectra of low LET particles were combined with experimental spectra to calculate RBE. To estimate accuracy of RBE, we calculated RBE by changing yield of low LET particles by ± 10% and ± 40%. Results At a small angle, maximum RBE by secondary fragments was 1.3 for 10% survival fractions. RBE values of fragments gradually decreased as the angle became larger. The shape of the LET spectra in the simulation reproduced the experimental spectra, but there was a discrepancy between the simulation and experiment for the relative yield of fragments. When the yield of low LET particles was changed by ± 40%, the change in RBE was smaller than 10%. Conclusions An RBE of 1.3 was expected for secondary fragments emitted at a small angle. Although, we observed a discrepancy in the relative yield of secondary fragments between simulation and experiment, precision of RBE was not so sensitive to the yield of low LET particles.

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Section: A Cr-39 Plastic Charged Particle Detectorsmentioning

confidence: 99%

Estimations of relative biological effectiveness of secondary fragments in carbon ion irradiation of water using CR‐39 plastic detector and microdosimetric kinetic model

et al. 2019

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“…This is because the dosimetry is based on LET spectroscopy [14,15], and the autoradiography [12,13] has sub-micron position resolution under optical microscopy. Several co-visualization methods of cells and ion tracks have been developed with CR-39.…”

Section: Introductionmentioning

confidence: 99%

Validating α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors

Kodaira

Konishi

et al. 2017

PLoS ONE

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Recently, 211At has received increasing attention as a potential radionuclide for cancer radioimmunotherapy. It is a α-particle emitter, which is extremely effective against malignant cells. We demonstrate a method to verify the efficiency of 211At-labeled trastuzumab antibodies (211At-trastuzumab) against HER2 antigens, which has not been determined for radioimmunotherapy. A CR-39 plastic nuclear detector is used for measuring the position and the linear energy transfer (LET) of individual 211At α- particle tracks. The tracks and 211At-trastuzumab-binding cells were co-visualized by using the geometric information recorded on the CR-39. HER2-positive human gastric cancer cells (NCI-N87), labelled with 211At-trastuzumab, were dropped on the centre of the CR-39 plate. Microscope images of the cells and the corresponding α-tracks acquired by position matching were obtained. In addition, 3.5 cm × 3.5 cm macroscopic images of the whole plate were acquired. The distribution of number of α-particles emitted from single cells suggests that 80% of the 211At-trastuzumab-binding cells emitted α-particles. It also indicates that the α-particles may strike the cells several times along their path. The track-averaged LET of the α-particles is evaluated to be 131 keV/μm. These results will enable quantitative evaluation of delivered doses to target cells, and will be useful for the in vitro assessment of 211At-based radioimmunotherapeutic agents.

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“…The result after etching is a conical pit, referred to as a nuclear track, in the surface of the PNTD. The size of the elliptical interface of the nuclear track and the post-etch surface of the CR-39 layer is proportional to the LET of the charged particle that produced the original latent damage trail 14,15 . Scanning the post etch surface by means of AFM permits the dimensions of the elliptical nuclear tracks to be measured 16 .…”

Section: Methodsmentioning

confidence: 99%

“…Since elliptical track size is proportional to LET, an LET spectrum and integrated values of absorbed dose and dose equivalent can be determined. The measured size of each track is converted to LET by means of an empirically determined detector response function found by measuring tracks of known LET from heavy ion exposures 13,15 . The detector response function was obtained by means of exposure and subsequent readout of CR-39 to beams of known LET particles (i.e.…”

Section: Methodsmentioning

confidence: 99%

“…According to the uncertainty study in LET specrum 24 , the uncertainty from calibration curve ranges from 1.1% to 9.4% in this work for LET ≥15 keV/µm. The considerable uncertainty comes from statistics in the bin consisting of LET spectrum because, (1) the LET of a track is found as a function of a power law equation 15 , (2) the binning of the LET spectrum 10,25 is very low resolution (the ratio of LET bin width to the center value of LET~10%), (3) given these two facts, small changes in the measurement of a track, due to AFM or optical microscope analysis or whatever, translate into only small changes in LET, and (4) because of the binning, small changes in LET usually do not translate into any change at all. Therefore, the current measurement method of LET spectrum is not particularly sensitive to the precision of individual track measurements.…”

Section: Methodsmentioning

confidence: 99%

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Contribution to dose in healthy tissue from secondary target fragments in therapeutic proton, He and C beams measured with CR-39 plastic nuclear track detectors

Kodaira

Kitamura

Kurano

et al. 2019

Sci Rep

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The linear energy transfer (LET) spectrum, absorbed dose and dose equivalent from secondary particles of LET ∞ H 2 O ≥15 keV/μm deposited within the plateau of the Bragg curve in primary particle-induced nuclear target fragmentation reactions in tissue during proton and heavy ion radiotherapy were measured using CR-39 plastic nuclear track detectors and analyzed by means of atomic force microscopy. It was found that secondary target fragments contributed 20% to dose equivalent for primary protons (157 MeV), 13% for primary helium ions (145 MeV/n) and 4% for primary carbon ions (383 MeV/n), respectively. Little research has been done on the contribution from these particles to primary given dose. The smaller contribution measured for energetic carbon ion beams compared to proton beams can be considered an advantage of carbon ion radiotherapy over proton radiotherapy.

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A performance test of a new high-surface-quality and high-sensitivity CR-39 plastic nuclear track detector – TechnoTrak

Cited by 41 publications

References 37 publications

Estimations of relative biological effectiveness of secondary fragments in carbon ion irradiation of water using CR‐39 plastic detector and microdosimetric kinetic model

Estimations of relative biological effectiveness of secondary fragments in carbon ion irradiation of water using CR‐39 plastic detector and microdosimetric kinetic model

Validating α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors

Contribution to dose in healthy tissue from secondary target fragments in therapeutic proton, He and C beams measured with CR-39 plastic nuclear track detectors

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