A perinatal study of toluene in CD-1 mice*1

Reproductive and Developmental Toxicity of Toluene: A Review

“…The association between toluene exposure and fetotoxicity is also supported by effects on fetal somatic development in several other studies (20)(21)(22)(23)(24), which are summarized in Table 3. Effects oftoluene exposure on late fetal weights and skeletal maturation were reported in rats and mice; data in rabbits are weak.…”

“…Prolonged maternal exposure to 2000 ppm toluene for 6 hr/day before and during gestation clearly had a marked effect on postnatal weight gain ofrat pups up to weaning. In contrast, maternal exposures to 400 ppm for 6 hr/day on days 7 to 16 ofgestation in the study by Courtney et al (24) had no significant effect on pup body weights, although the toluenetreated pups were somewhat heavier than controls (Table 5). There is also limited evidence for retardation of postnatal physical development as assessed by appearance ofdevelopmental landmarks such as hair eruption and eye opening (27).…”

“…A significant increase in the incidence offetuses with a 13/13 rib profile from dams that had been exposed to 400 ppm toluene for 7 hr/day on days 7 to 16 of gestation was also reported (24). It is unclear whether this result is adverse, since this profile is considered normal.…”

Reproductive and developmental toxicity of toluene: a review.

“…Mouse Table 5. Pstnatal pup mean body weights (grms) for rats (19) and mice (24). dTotal daily intakes reported to cause toxicity in the fetuses, dams, or both.…”

“…In mice, a significant increase was also reported in the incidence of SRF resulting from exposures to 266 ppm toluene for 12 hr/day on days 6 to 15 ofgestation (20). A significant increase in the incidence offetuses with a 13/13 rib profile from dams that had been exposed to 400 ppm toluene for 7 hr/day on days 7 to 16 of gestation was also reported (24). It is unclear whether this result is adverse, since this profile is considered normal.…”