A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Bennett, Gary J.; Xie, Yuefeng F.

doi:10.1016/0304-3959(88)90209-6

Cited by 4,841 publications

(3,231 citation statements)

References 27 publications

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“…Neuropathic allodynia Under halothane inhalation anesthesia, rats received either a unilateral tight ligation of the L5 and L6 spinal nerves (Kim & Chung, 1992) or a chronic constriction injury to the left sciatic nerve (Bennett & Xie, 1988). Antiallodynic effects of A-317491 were evaluated at least 1 week after surgery.…”

Section: â100mentioning

confidence: 99%

Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

McGaraughty

Wismer

Zhu

et al. 2003

British J Pharmacology

170

129

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1 We have recently reported that systemic delivery of A-317491, the first non-nucleotide antagonist that has high affinity and selectivity for blocking P2X 3 homomeric and P2X 2/3 heteromeric channels, is antinociceptive in rat models of chronic inflammatory and neuropathic pain. In an effort to further evaluate the role of P2X 3 /P2X 2/3 receptors in nociceptive transmission, A-317491 was administered either intrathecally or into the hindpaw of a rat in several models of acute and chronic nociception. 2 Intraplantar (ED 50 ¼ 300 nmol) and intrathecal (ED 50 ¼ 30 nmol) injections of A-317491 produced dose-related antinociception in the CFA model of chronic thermal hyperalgesia. Administration of A-317491 by either route was much less effective to reduce thermal hyperalgesia in the carrageenan model of acute inflammatory hyperalgesia. 3 Intrathecal, but not intraplantar, delivery of A-317491 attenuated mechanical allodynia in both the chronic constriction injury and L5-L6 nerve ligation models of neuropathy (ED 50 ¼ 10 nmol for both models). Intrathecal injections of A-317491 did not impede locomotor performance. 4 Both routes of injection were effective in reducing the number of nocifensive events triggered by the injection of formalin into a hindpaw. Nocifensive behaviors were significantly reduced in both the first and second phases of the formalin assay (intrathecal ED 50 ¼ 10 nmol, intraplantar ED 50 4300 nmol). Nocifensive behaviors induced by the P2X receptor agonist a,b-meATP were also significantly reduced by intraplantar injection of A-317491. 5 These data indicate that both spinal and peripheral P2X 3 /P2X 2/3 receptors have significant contributions to nociception in several animal models of nerve or tissue injury. Intrathecal administration of A-317491 appears to be more effective than intraplantar administration to reduce tactile allodynia following peripheral nerve injury.

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Section: â100mentioning

confidence: 99%

Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

McGaraughty

Wismer

Zhu

et al. 2003

British J Pharmacology

170

129

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“…68 This model of injury has been used to test the effects of spinal intrathecal cell transplants that secrete BDNF to relieve the pain-related behaviors, 69 and the same pain model was subsequently used before injection of rAAV/BDNF for over-expression of BDNF in the spinal cord. Under ketamine/xylazine/acepromazine anesthesia, the right common sciatic nerve was exposed at the level of the middle thigh by blunt dissection through the biceps femoris.…”

Section: Chronic Constriction Injury (Cci)mentioning

confidence: 99%

Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

et al. 2002

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Changing the levels of neurotrophins in the spinal cord micro-environment after nervous system injury has been proposed to recover normal function, such that behavioral response to peripheral stimuli does not lead to chronic pain. We have investigated the effects of recombinant adenoassociated viral (rAAV)-mediated over-expression of brainderived neurotrophic factor (BDNF) in the spinal cord on chronic neuropathic pain after unilateral chronic constriction injury (CCI) of the sciatic nerve. The rAAV-BDNF vector was injected into the dorsal horn at the thirteenth thoracic

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“…Animals were subjected to unilateral constriction injury of the right sciatic nerve (CCI) 30 under sodium pentobarbital anaesthesia (50 mg/kg, intraperitoneally). Unilateral CCI was performed by placing four chromic gut ligatures around the right sciatic nerve.…”

Section: Methodsmentioning

confidence: 99%

Peripheral nerve injury induces adult brain neurogenesis and remodelling

Rusanescu

Mao

2016

J Cellular Molecular Medi

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Unilateral peripheral nerve chronic constriction injury (CCI) has been widely used as a research model of human neuropathic pain. Recently, CCI has been shown to induce spinal cord adult neurogenesis, which may contribute to the chronic increase in nociceptive sensitivity. Here, we show that CCI also induces rapid and profound asymmetrical anatomical rearrangements in the adult rodent cerebellum and pons. This remodelling occurs throughout the hindbrain, and in addition to regions involved in pain processing, also affects other sensory modalities. We demonstrate that these anatomical changes, partially reversible in the long term, result from adult neurogenesis. Neurogenic markers Mash1, Ngn2, doublecortin and Notch3 are widely expressed in the rodent cerebellum and pons, both under normal and injured conditions. CCI‐induced hindbrain structural plasticity is absent in Notch3 knockout mice, a strain with impaired neuronal differentiation, demonstrating its dependence on adult neurogenesis. Grey matter and white matter structural changes in human brain, as a result of pain, injury or learned behaviours have been previously detected using non‐invasive neuroimaging techniques. Because neurogenesis‐mediated structural plasticity is thought to be restricted to the hippocampus and the subventricular zone, such anatomical rearrangements in other parts of the brain have been thought to result from neuronal plasticity or glial hypertrophy. Our findings suggest the presence of extensive neurogenesis‐based structural plasticity in the adult mammalian brain, which may maintain a memory of basal sensory levels, and act as an adaptive mechanism to changes in sensory inputs.

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Cited by 4,841 publications

References 27 publications

Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

Peripheral nerve injury induces adult brain neurogenesis and remodelling

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Cited by 4,841 publications

References 27 publications

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord

Peripheral nerve injury induces adult brain neurogenesis and remodelling

Contact Info

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Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Effects of A‐317491, a novel and selective P2X₃/P2X_2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration