A peripheral nerve sheath tumour as a cause of nasal obstruction

Manganaris, Argyrios; Tsompanidou, C.; Manganaris, Theodoros

doi:10.1017/s0022215106004440

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…A review of the English literature between 1966 and 2014 was performed. Clinical series of ''head and neck soft tissue tumors'' were selected if critical information about sinonasal tract neurofibroma were included (Table 4) [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Foreign language articles were only included if they were published alongside an English translation.…”

Section: Methodsmentioning

confidence: 99%

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Azani

Bishop

Thompson

2014

Head and Neck Pathol

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Neurofibroma (NF), a benign peripheral nerve sheath tumor, is very uncommon in the sinonasal tract, with only a few reported cases in the English literature. Cases within the files of the authors' institutions confined to the sinonasal tract were compared to cases reported in the English literature (Medline 1966-2014). The 12 patients included 6 females and 6 males, aged 26-75 years (mean 46.2 years). The patients usually presented clinically with a mass lesion (n = 11), obstruction (n = 4) or pain (n = 3), with an average symptom duration of 42.9 months. Two patients had neurofibromatosis (NF1). Tumors involved the nasal cavity alone (n = 8), maxillary sinus alone (n = 2), or mixed sites (n = 2), with a range of 0.4-4.1 cm (mean 2.2 cm). The tumors were circumscribed, composed of spindled to wavy cells with curvilinear nuclei set in a background of collagenized stroma and mast cells. Nuclear palisading and perivascular hyalinization were not seen. Mitoses were scant. Pleomorphism, necrosis and increased cellularity were absent. By immunohistochemistry, the lesional cells were S100 protein, SOX10 and NFP positive, while CD34 highlighted the perineurium. INI1 was intact, with strong nuclear expression in all cases. All patients had surgical excision without recurrence (mean follow-up 8.6 years). The principle differential diagnoses include schwannoma, perineurioma, fibromatosis, and solitary fibrous tumor. NF of the sinonasal tract occurs in middle-aged patients without a gender predilection, usually with non-specific symptoms present for a long duration. Tumors are relatively large (mean 2.2), and usually affect one site only. Surgery is curative, with only 16.7 % NF1 associated. S100 protein, SOX10 and NFP highlight the Schwann cells, with CD34 highlighting the perineural fibroblasts.

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Section: Methodsmentioning

confidence: 99%

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Azani

Bishop

Thompson

2014

Head and Neck Pathol

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“…Surgical excision of sinonasal tumors significantly affects the patient's quality of life [ 18 ]. Sinonasal neurofibroma treatment varies from an endoscopic approach [ 5 , 6 , 9 , 10 ] to external approaches (e.g., midfacial degloving, lateral rhinotomies) [ 7 , 8 , 11 ]. In most cases, there was no recurrence at follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Due to its slow growth and the non-specific nature of the symptoms, it often takes more than four years to reach a diagnosis [4]. Only a few cases have been reported in the current literature [4][5][6][7][8][9][10][11][12]. We present the case of a patient with a sinonasal neurofibroma of exceptional size treated in our department.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of a Large Sinonasal Neurofibroma

Skalias¹,

Karamitsou²,

Poutoglidis³

et al. 2022

Cureus

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A neurofibroma is a benign peripheral nerve sheath tumor. Its appearance in the nose and paranasal sinuses is extremely rare. We present the case of a 61-year-old female with a large sinonasal neurofibroma. The patient was referred to our department due to the findings of a large invasive lesion originating from the left sinus with extension to the adjacent structures on computed tomography. A thorough examination revealed a mass within the left nasal cavity and exophthalmos. The initial symptoms of the disease probably appeared three years ago when she reported that she developed facial swelling following dental work. In the following period and due to reported blurred vision, she consulted with several medical specialists without receiving a diagnosis, while later she visited an otorhinolaryngologist, complaining of ear fullness, and local treatment was prescribed. Due to persistent symptoms, the patient was finally referred for computed tomography. Upon arrival at our department, she underwent a biopsy, which revealed the existence of a neurofibroma. The patient underwent endoscopic resection of the tumor and remains under close follow-up with no signs of recurrence. Sinonasal neurofibroma is a rare condition that presents with non-specific symptoms and may take years to reach a diagnosis. Open or endoscopic surgical resection seems to offer satisfactory results; however, similar cases reported in the literature are scarce.

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A Case of Neurofibroma Accompanying Organized Hematoma Extending into the Maxillary Sinus

Kim

Chung

2009

Korean J Otorhinolaryngol-Head Neck Surg

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A peripheral nerve sheath tumour as a cause of nasal obstruction

Cited by 3 publications

References 4 publications

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

Sinonasal Tract Neurofibroma: A Clinicopathologic Series of 12 Cases with a Review of the Literature

A Rare Case of a Large Sinonasal Neurofibroma

A Case of Neurofibroma Accompanying Organized Hematoma Extending into the Maxillary Sinus

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