A perspective on molybdenum biocompatibility and antimicrobial activity for applications in implants

Ribeiro, Andreza Maria; Flores-Sahagun, Thais Helena Sydenstricker; Paredes, R.C.

doi:10.1007/s10853-015-9664-y

Cited by 77 publications

(28 citation statements)

References 111 publications

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“…molybdenum‐rhenium coated struts have been used for applications within replacement heart‐valve components (Beall mitral valves) (Ribeiro et al . ).…”

Section: Resultsmentioning

confidence: 97%

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Rhenium and yttrium ions as antimicrobial agents against multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii biofilms

Slate

Shalamanova

Akhidime

2019

Lett Appl Microbiol

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Antimicrobial resistance presents major global concerns to patient health. In this study, metal ions of molybdenum, rhenium, yttrium and thallium were tested against bacteria in planktonic and biofilm form using one strain of Klebsiella pneumoniae and Acinetobacter baumannii. The antimicrobial efficacy of the metal ions was evaluated against the planktonic bacterial strains using minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations, whilst the efficacy of the metal ions against biofilms was tested using a crystal violet biofilm assay. Live Dead staining was used to visualize the antimicrobial activity elicited by the metal ions on the bacterial cell. The results showed that higher concentrations of the metals were required to inhibit the growth of biofilms (72·9 mg l−1 to 416·7 mg l−1), in comparison to their planktonic counterparts. MICs of the metal ions (<46·9 mg l−1) (planktonic cells) did not affect biofilm formation. Overall, rhenium and yttrium were effective antimicrobial agents. Molybdenum demonstrated the greatest level of biotoxicity. When taking into account these results and the known toxicity of thallium, it is possible that rhenium or yttrium ions could be developed as effective biocidal formulations in order to prevent transmission in healthcare environments. Significance and Impact of the Study The metal ions, molybdenum, rhenium, thallium and yttrium were tested against both Klebsiella pneumoniae and Acinetobacter baumannii in planktonic and biofilm forms. This research demonstrated that all the metal ions may be effective antimicrobial agents. However, molybdenum induced high levels of cytotoxicity, whilst, there was no significant difference in the toxicity of the other metal ions tested. When considering the results for the antimicrobial efficacy and biotoxicity of the metal ions, in conjunction with the known toxicity of thallium in certain chemical compositions, it was concluded that overall rhenium or yttrium ions may be effective antimicrobial agents, one potential application may be utilizing these metal ions in hospital surface cleaning formulations.

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“…molybdenum‐rhenium coated struts have been used for applications within replacement heart‐valve components (Beall mitral valves) (Ribeiro et al . ).…”

Section: Resultsmentioning

confidence: 97%

“…Rhenium ions were also tested in combination with ciprofloxacin (in vivo), where they destroyed bacterial cells by disrupting DNA gyrase synthesis (Lecina et al 2014). molybdenum-rhenium coated struts have been used for applications within replacement heart-valve components (Beall mitral valves) (Ribeiro et al 2016).…”

Section: Resultsmentioning

confidence: 99%

Rhenium and yttrium ions as antimicrobial agents against multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii biofilms

Slate

Shalamanova

Akhidime

2019

Lett Appl Microbiol

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“…In the case of VP-MoS 2 , a slight increase in the metabolic activity before and after transplantation was observed, in good agreement with other biological studies in molybdenum-based biomaterials. 17,[38][39][40] Finally, endothelial cells growing over VP-MoS 2 presented a more outstretched phenotype, in contrast with other hydrogels, were cells presented a rounded morphology (Fig. S10).…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 97%

Facile one-pot exfoliation and integration of 2D layered materials by dispersion in a photocurable polymer precursor

et al. 2017

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“…Mo is another refractory metal that is a reasonable choice for use as a needle base material due to its mechanical strength, resistance to corrosion, excellent machinability and biocompatibility. 24 We considered making entire needles of Re, but it is much more expensive than Mo and does not possess many of the desirable characteristic of Mo. 13 Mo-Re alloys are often formed to offer protection against oxidation, wear and corrosion.…”

Section: Cvd Of Re On Mo Needles and Evaluation Of Re Leachingmentioning

confidence: 99%

Neutron‐activatable needles for radionuclide therapy of solid tumors

Kim

Narayan

Lü

et al. 2017

J Biomedical Materials Res

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Various approaches have been undertaken to enhance the delivery of therapeutic agents, including tissue-killing radionuclides, into solid tumors. Here we describe the preparation of conical needles composed of Ti and Mo coated by pulsed laser deposition or chemical vapor deposition with elements (Ho and Re) that can readily yield radioactive isotopes following irradiation in a neutron flux. The radioactive needles, whose design were based on solid microneedle arrays used in transdermal drug delivery, can be produced with minimal handling of radioactivity and subsequently inserted into tumors as a means of internal radiation therapy. Ho and Re, were specifically chosen because of their large neutron capture cross-sections as well as the desirable radiotherapeutic properties of the resultant radionuclides. Neutron-absorbing shields were also developed to prevent the production of unwanted radionuclides after neutron irradiation of the needle base materials. Neutron activation calculations showed that therapeutically significant amounts of radionuclides can be produced for treating solid tumors. Stability studies demonstrated that Re did not leach off the Mo needles. These coated neutron-activatable needles offer a new approach to internal radiation therapy of tumors that allows precise tailoring of the absorbed radiation dose delivered to the tumor by controlling the coating thickness and the irradiation time.

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A perspective on molybdenum biocompatibility and antimicrobial activity for applications in implants

Cited by 77 publications

References 111 publications

Rhenium and yttrium ions as antimicrobial agents against multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii biofilms

Rhenium and yttrium ions as antimicrobial agents against multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii biofilms

Facile one-pot exfoliation and integration of 2D layered materials by dispersion in a photocurable polymer precursor

Neutron‐activatable needles for radionuclide therapy of solid tumors

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