A perspective on the safety of parabens as preservatives in wound care products

Torfs, Eveline; Brackman, Gilles

doi:10.1111/iwj.13521

Cited by 21 publications

(7 citation statements)

References 98 publications

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“…Based on early assessments, parabens are classified among the oldest and most commonly used preservatives in various food, cosmetics, and pharmaceutical products. Parabens and their esters are generally used in topical formulations as they are chemically stable and have broad-spectrum antimicrobial activity [ 214 , 215 ]. In recent years, as far as safety is concerned, parabens have been the most criticized among other preservatives.…”

Section: Recent Trends In Preservationmentioning

confidence: 99%

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

et al. 2023

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The global market of food, cosmetics, and pharmaceutical products requires continuous tracking of harmful ingredients and microbial contamination for the sake of the safety of both products and consumers as these products greatly dominate the consumer’s health, directly or indirectly. The existence, survival, and growth of microorganisms in the product may lead to physicochemical degradation or spoilage and may infect the consumer at another end. It has become a challenge for industries to produce a product that is safe, self-stable, and has high nutritional value, as many factors such as physical, chemical, enzymatic, or microbial activities are responsible for causing spoilage to the product within the due course of time. Thus, preservatives are added to retain the virtue of the product to ensure its safety for the consumer. Nowadays, the use of synthetic/artificial preservatives has become common and has not been widely accepted by consumers as they are aware of the fact that exposure to preservatives can lead to adverse effects on health, which is a major area of concern for researchers. Naturally occurring phenolic compounds appear to be extensively used as bio-preservatives to prolong the shelf life of the finished product. Based on the convincing shreds of evidence reported in the literature, it is suggested that phenolic compounds and their derivatives have massive potential to be investigated for the development of new moieties and are proven to be promising drug molecules. The objective of this article is to provide an overview of the significant role of phenolic compounds and their derivatives in the preservation of perishable products from microbial attack due to their exclusive antioxidant and free radical scavenging properties and the problems associated with the use of synthetic preservatives in pharmaceutical products. This article also analyzes the recent trends in preservation along with technical norms that regulate the food, cosmetic, and pharmaceutical products in the developing countries.

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Section: Recent Trends In Preservationmentioning

confidence: 99%

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

et al. 2023

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“…Then, the pH was adjusted to 6 using triethanolamine. [12][13][14][15] The NLC formulation with least particle size and polydispersity index (PDI) and zeta potential within the acceptable range (TF-4) were added to the prepared gel slowly with continuous stirring.…”

Section: Preparation Of Gel and Loading Of Tre-nlcmentioning

confidence: 99%

Untitled

2023

AJP

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Aims:The current study was focussed on the fabrication of nanostructered lipid carrier (NLC) of tretinoin (TRE) followed by its incorporation into hyaluronic acid (HA)-loaded carbapol 940 gel aiming to improve acne treatment. Materials and Methods: The TRE-NLC was fabricated using melt-emulsification and ultrasonication method. The fabricated NLC was studied for its particle size, zeta potential, polydispersity index, morphology, and entrapment efficiency of TRE. The gel containing HA and TRE-NLC were evaluated for pH, spreadability, extrudability, bloom strength, and viscosity. The in vitro release studies and in vitro occlusivity test for the formulated gel and marketed gel were carried out. Results and Discussion: The formulated gel showed better release of 86.32% when compared to marketed gel with 38.52% release in 8 h. Occlusion factor can be related to skin hydration based upon the ability to prevent water loss from the surface of the skin which was found to be 42.29% for the formulated gel and 4.76% for the marketed gel. Conclusion: The combination of TRE-loaded NLCs and HA gel may provide a more effective treatment for acne by diminishing the dryness than either TRE or HA gel alone.

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“…Since tars possess antibacterial properties, their use in topical formulations does not require the use of preservative agents. Preservatives, such as parabens, incorporated into topical skin products have been criticized for their potential to induce allergic contact dermatitis 37 . Designing formulations without preservatives is a simple way to contribute to the safety of topical products, improving the acceptance by patients.…”

Section: Pros and Cons For Tars As Antipsoriatic Therapiesmentioning

confidence: 99%

Updated view of tars for psoriasis: what have we learned over the last decade?

et al. 2022

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Tars are one of the most effective, unknown, and oldest therapies for psoriasis. They include coal tar (CT) and biomass‐derived products. These treatments, particularly the CT, have proven to be cost‐effective with long remission times compared to other systemic or topical treatments. However, they have hardly evolved in recent years, as they are not well‐embraced by clinicians or patients because of concerns regarding cosmesis and safety. This review summarizes current knowledge about the chemical characterization, mechanism of action, toxicity, and clinical studies supporting the use of tars for psoriasis over the last decade. Trends within these above aspects are reviewed, and avenues of research are identified. CT is rich in polycyclic aromatic hydrocarbons, whereas biomass‐derived tars are rich in phenols. While the activation of the aryl hydrocarbon receptor is involved in the antipsoriatic effect of CT, the mechanism of action of biomass‐derived products remains to be elucidated. No conclusive evidence exists about the risk of cancer in psoriasis patients under CT treatment. Large, randomized, double‐blind, controlled clinical trials are necessary to promote the inclusion of tars as part of modern therapies for psoriasis.

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A perspective on the safety of parabens as preservatives in wound care products

Cited by 21 publications

References 98 publications

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

Polyphenols: Natural Preservatives with Promising Applications in Food, Cosmetics and Pharma Industries; Problems and Toxicity Associated with Synthetic Preservatives; Impact of Misleading Advertisements; Recent Trends in Preservation and Legislation

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Updated view of tars for psoriasis: what have we learned over the last decade?

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