A pH, glucose, and dopamine triple-responsive, self-healable adhesive hydrogel formed by phenylborate–catechol complexation

Abstract

A pH, glucose, and dopamine triple-responsive, self-healable and adhesive polyethylene glycol hydrogel was developed via the formation of phenylborate–catechol complexation.

Double‐Hydrophobic‐Coating through Quenching for Hydrogels with Strong Resistance to Both Drying and Swelling

“…This kind of physical adsorption‐based adhesion may also be applicable for various dry surfaces (e.g., metals, ceramics, and plastics) and wet surfaces (e.g., hydrogels and biotissues); however, future extensive studies should be carried out to further clarify this. The adhesive property of our system is comparable to commonly used mussel‐inspired catechol‐based hydrogels and other recently developed adhesive hydrogels that rely on supramolecular interactions for adhesion (Table S1, Supporting Information) . Notably, while most adhesive hydrogels (apart from nanoparticle adhesives) require internal modification of the chemical structure—which ultimately changes the properties compared to the original unmodified hydrogel—our strategy only alters the surface structure.…”

“…The adhesive property of our system is comparable to commonly used mussel-inspired catechol-based hydrogels and other recently developed adhesive hydrogels that rely on supramolecular interactions for adhesion (Table S1, Supporting Information). [26][27][28][29][30][31] Notably, while most adhesive hydrogels (apart from nanoparticle adhesives) require internal modification of the chemical structure-which ultimately changes the properties compared to the original unmodified hydrogel-our strategy only alters the surface structure. Hence, this approach could be used to easily turn various nonadhesive hydrogels into adhesive hydrogels, while retaining the original bulk properties.…”

Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers

“…Finally, we demonstrate that these materials can be used as bulk cell encapsulants for cell delivery applications aimed to soft tissue engineering applications, [69][70][71][72] owing to the mild mixing and recovery conditions for their preparation and reconstruction. Such functionalities in terms of multi-responsiveness and healability, combined with excellent cytocompatible properties, have not been extensively exploited in previous boronic acid-based studies, 33,60,64,73 and hence, we anticipate that our study will be inspirational towards the development of functionally more complex, yet synthetically accessible, materials for the biomedical field.…”

“…The cytotoxicity of the constructs was assessed by an extraction test according to ISO 10993-5 standard as described by previously published studies. 64,75,76 The gels were immersed in DMEM at an extrac- …”

“…59,60 Recently, soft healable gels based on the reversible bonding of boronic acids with diols have also emerged in the form of multi-responsive polymer blends. [61][62][63][64] Inspired by these studies and our previous work on boronate ester constructs for chemical logic operations 65 and cell surface engineering, 66,67 we designed a simple boronic acidbased nanocomposite that exhibits complex, albeit predictable, physicochemical and mechanical behaviour as a multihealable model platform for cell encapsulation. Our proposed system comprises a synthetic thermoresponsive boronic acid copolymer that is crosslinked with poly(vinyl alcohol) (PVA) to form cytocompatible hydrogels within seconds under physiological conditions (Fig.…”